Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.45 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.45 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13876076 | 0.77 | EPHX2 (1.00) | EPHX2LMNAMAPK1NLRP1ERCC1 | |
| SCHEMBL4190539 | 0.72 | EPHX2 (0.63) | EPHX2LMNAMAPK1NLRP1P2RX7 | |
| SCHEMBL4199381 | 0.72 | P2RX7 (0.53) | EPHX2LMNAMAPK1NLRP1P2RX7 | |
| SCHEMBL5646507 | 0.70 | LMNA (0.70) | EPHX2LMNAMAPK1NLRP1MAPT | |
| SCHEMBL30802565 | 0.69 | LMNA (0.72) | EPHX2LMNAMAPK1NLRP1MAPT | |
| SCHEMBL29336072 | 0.69 | LMNA (0.72) | EPHX2LMNAMAPK1NLRP1MAPT | |
| SCHEMBL5645070 | 0.69 | LMNA (0.64) | EPHX2LMNAMAPK1NLRP1MAPT | |
| SCHEMBL5643117 | 0.68 | LMNA (0.71) | EPHX2LMNAMAPK1NLRP1MAPT | |
| SCHEMBL29335953 | 0.68 | LMNA (0.71) | EPHX2LMNAMAPK1NLRP1MAPT | |
| SCHEMBL5642926 | 0.68 | LMNA (0.75) | EPHX2LMNAMAPK1NLRP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987004-A2 | SUBSTITUTED PYRIDINEAMIDE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007098352-A2 | SUBSTITUTED PYRIDINEAMIDE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-08-30 | — | — | WO | disclosed |