Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | ELANE | P08246 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6325593 | 0.83 | L3MBTL1 (0.55) | ALDH1A1HPGDELANEKDM4ESMN1; SMN2 | |
| SCHEMBL9944385 | 0.78 | ELANE (0.46) | ALDH1A1ELANEKDM4ECA12CA1 | |
| SCHEMBL28241780 | 0.78 | MAPT (0.50) | ALDH1A1ELANEKDM4ECA12CA1 | |
| SCHEMBL17260775 | 0.77 | ELANE (0.49) | ALDH1A1HPGDELANEKDM4ESMN1; SMN2 | |
| SCHEMBL28430192 | 0.76 | GRM4 (0.43) | ALDH1A1HPGDELANEKDM4ECA12 | |
| SCHEMBL28423158 | 0.76 | MAPT (0.46) | ALDH1A1ELANEKDM4ECA12CA1 | |
| Water SCHEMBL15167306 | 0.75 | KDM4E (0.55) | ALDH1A1HPGDELANEKDM4ESMN1; SMN2 | |
| SCHEMBL936114 | 0.75 | KDM4E (0.55) | ALDH1A1HPGDELANEKDM4ESMN1; SMN2 | |
| SCHEMBL4147133 | 0.75 | KDM4E (0.61) | ALDH1A1ELANEKDM4ECA12CA1 | |
| SCHEMBL4069169 | 0.74 | MAPT (0.45) | ALDH1A1ELANEKDM4ECA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973908-A2 | PROCESSES AND INTERMEDIATES USEFUL FOR PREPARING INTEGRASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2008-10-01 | — | — | EP | disclosed |
| US-20080039487-A1 | Processes and intermediates useful for preparing integrase inhibitor compounds | GILEAD SCIENCES, LLC | 2008-02-14 | — | — | US | disclosed |
| US-20080039487-A1 | Processes and intermediates useful for preparing integrase inhibitor compounds | GILEAD SCIENCES, LLC | 2008-02-14 | — | — | US | disclosed |
| WO-2007076005-A2 | PROCESSES AND INTERMEDIATES USEFUL FOR PREPARING INTEGRASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076005-A2 | PROCESSES AND INTERMEDIATES USEFUL FOR PREPARING INTEGRASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
| US-20070072831-A1 | Integrase inhibitor compounds | GILEAD SCIENCES, INC. | 2007-03-29 | — | — | US | disclosed |
| US-20070072831-A1 | Integrase inhibitor compounds | GILEAD SCIENCES, INC. | 2007-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072831-A1 | Integrase inhibitor compounds | TYMP, CDKN1A, PAICS | ALDH1A1 1987/4885HPGD 1068/4885ELANE 2360/4885 |
| US-20080039487-A1 | Processes and intermediates useful for preparing integrase inhibitor compounds | TYMP, DUT, SAMHD1 | ALDH1A1 1879/4885HPGD 981/4885ELANE 3607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.