Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | THPO | P40225 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4654585 | 0.78 | CYP3A4 (0.46) | MEN1KMT2AMAPTLMNACYP2D6 | |
| SCHEMBL4653378 | 0.77 | MEN1 (0.46) | MEN1KMT2AMAPTLMNACYP2D6 | |
| SCHEMBL4653345 | 0.75 | MAPT (0.44) | MEN1KMT2AMAPTLMNACYP2D6 | |
| SCHEMBL4653651 | 0.74 | LMNA (0.44) | MAPTLMNASIGMAR1NPSR1KDM4E | |
| SCHEMBL4652287 | 0.73 | CYP3A4 (0.41) | MEN1KMT2AMAPTLMNACYP2D6 | |
| SCHEMBL4289774 | 0.73 | MEN1 (0.51) | MEN1KMT2AMAPTLMNACYP2D6 | |
| SCHEMBL4289771 | 0.73 | MEN1 (0.51) | MEN1KMT2AMAPTLMNACYP2D6 | |
| SCHEMBL28392280 | 0.64 | LMNA (0.72) | MEN1KMT2AMAPTLMNACYP2D6 | |
| Flunarizine SCHEMBL1649226 | 0.62 | LMNA (0.95) | MEN1KMT2AMAPTLMNACYP2D6 | |
| SCHEMBL10362320 | 0.62 | CYP3A4 (0.42) | MEN1KMT2AMAPTLMNACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987009-A1 | CYCLOUREA COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | EURO-CELTIQUE S.A. (LU) | 2008-11-05 | — | — | EP | claimed |
| WO-2007085357-A1 | CYCLOUREA COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | EURO-CELTIQUE S.A. (LU) | 2007-08-02 | — | — | WO | claimed |