Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 9/20 | 0.73 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.73 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.73 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.73 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.73 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.73 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.73 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.73 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.73 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.73 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.73 |
| ▸ | ACHE | P22303 | 4/20 | 0.73 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.68 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.68 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.68 |
| ▸ | DRD3 | P35462 | 2/20 | 0.67 |
| ▸ | ATP4A | P20648 | 1/20 | 0.67 |
| ▸ | ATP4B | P51164 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL465440 | 1.00 | HDAC3 (0.73) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL465560 | 1.00 | HDAC3 (0.73) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL465443 | 0.98 | ACHE (0.75) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL465492 | 0.95 | ACHE (0.75) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL9320573 | 0.93 | ATP4A (0.74) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL9006360 | 0.93 | ACHE (0.68) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5141117 | 0.92 | ATP4A (0.76) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5639983 | 0.90 | ACHE (0.68) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL31063784 | 0.88 | ACHE (0.74) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL11624627 | 0.88 | ACHE (0.74) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194981-B1 | BISBENZIMIDAZOLES AS ANTIMALARIAL AGENTS | UNIV MONS HAINAUT (BE) | 2011-11-23 | — | — | EP | disclosed |
| US-20100160402-A1 | Bisbenzimidazoles as antimalarial agents | XAVIER UNIVERSITY OF LOUISIANA | 2010-06-24 | — | — | US | disclosed |
| US-20100160402-A1 | Bisbenzimidazoles as antimalarial agents | XAVIER UNIVERSITY OF LOUISIANA | 2010-06-24 | — | — | US | disclosed |
| US-20100160402-A1 | Bisbenzimidazoles as antimalarial agents | XAVIER UNIVERSITY OF LOUISIANA | 2010-06-24 | — | — | US | disclosed |
| EP-2194981-A1 | BISBENZIMIDAZOLES AS ANTIMALARIAL AGENTS | Université de Mons-Hainaut (BE) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009043902-A1 | BISBENZIMIDAZOLES AS ANTIMALARIAL AGENTS | UNIVERSITE DE MONS HAINAUT (BE) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160402-A1 | Bisbenzimidazoles as antimalarial agents | NQO2, SQOR, CPS1 | HDAC3 237/4885HDAC4 1357/4885HDAC1 963/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.