Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR3 | P25089 | 5/20 | 0.64 |
| ▸ | FPR2 | P25090 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | HTR3A | P46098 | 3/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.50 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.50 |
| ▸ | STK10 | O94804 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4654817 | 0.97 | KMT2A (0.60) | FPR3FPR2MEN1KMT2AHTR3A | |
| SCHEMBL4654735 | 0.86 | KMT2A (0.66) | FPR3FPR2MEN1KMT2AHTR3A | |
| SCHEMBL4654794 | 0.85 | FPR3 (0.62) | FPR3FPR2MEN1KMT2AHTR3A | |
| SCHEMBL4654898 | 0.83 | KMT2A (0.70) | MEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL14006065 | 0.81 | HTR3A (0.73) | FPR3FPR2MEN1KMT2AHTR3A | |
| SCHEMBL17678095 | 0.80 | LMNA (0.58) | FPR3FPR2KMT2AHTR3A | |
| SCHEMBL4654739 | 0.80 | HTR3A (0.67) | FPR3FPR2MEN1KMT2AHTR3A | |
| SCHEMBL4654811 | 0.79 | HTR3A (0.55) | MEN1KMT2AHTR3AADRA2AADRA2B | |
| SCHEMBL2683962 | 0.79 | FPR3 (1.00) | FPR3FPR2 | |
| SCHEMBL29348969 | 0.78 | LMNA (0.55) | FPR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991528-A2 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | Siena Biotech S.p.A. (IT) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007098826-A2 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | SIENA BIOTECH S.P.A. (IT) | 2007-09-07 | — | — | WO | disclosed |