SCHEMBL4655015

SCHEMBL4655015

CC(CO)NC(C)C(=O)c1ccccc1.CC(CO)NC(C)C(=O)c1ccccc1Cl.CC(NC(C)(C)CO)C(=O)c1ccccc1Cl

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2B6 P20813 1/20 0.55
SLC6A2 P23975 3/20 0.39
CHRNA1 P02708 2/20 0.39
CHRNG P07510 2/20 0.39
CHRNB1 P11230 2/20 0.39
CHRNB2 P17787 2/20 0.39
CHRNB4 P30926 2/20 0.39
SLC6A4 P31645 2/20 0.39
CHRNA3 P32297 2/20 0.39
CHRNA4 P43681 2/20 0.39
SLC6A3 Q01959 2/20 0.39
CHRND Q07001 2/20 0.39
ITGA5 P08648 1/20 0.39
CYP2C19 P33261 1/20 0.39
HRH1 P35367 1/20 0.39
CHRNA7 P36544 1/20 0.39
OPRK1 P41145 1/20 0.39
KCNH2 Q12809 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
ALDH1A1 P00352 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4399935 0.86 CYP2B6 (0.59) CYP2B6SLC6A2CHRNA1CHRNGCHRNB1
SCHEMBL4401492 0.83 NPC1 (0.48) CYP2C19SMN1; SMN2ALDH1A1NPC1RAB9A
SCHEMBL4393402 0.78 PGR (0.46) HRH1KCNH2SMN1; SMN2ALDH1A1NPC1
SCHEMBL6059596 0.73 SLC6A2 (0.55) SLC6A2CHRNA1CHRNGCHRNB1CHRNB2
Hydrochloric Acid SCHEMBL30450072 0.71 SLC6A2 (0.56) SLC6A2CHRNA1CHRNGCHRNB1CHRNB2
SCHEMBL29486913 0.71 CYP2B6 (1.00) CYP2B6SLC6A2CHRNA1CHRNGCHRNB1
SCHEMBL2955633 0.71 CYP2B6 (1.00) CYP2B6SLC6A2CHRNA1CHRNGCHRNB1
SCHEMBL2955630 0.71 CYP2B6 (1.00) CYP2B6SLC6A2CHRNA1CHRNGCHRNB1
SCHEMBL1226857 0.71 CYP2B6 (1.00) CYP2B6SLC6A2CHRNA1CHRNGCHRNB1
SCHEMBL4393537 0.68 CYP2B6 (0.63) CYP2B6SLC6A2CHRNA1CHRNGCHRNB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1993525-A1 THE USE OF BETA-AMINOALCOHOLS IN THE TREATMENT OF INFLAMMATORY DISORDERS AND PAIN Sosei R&D Ltd. (GB) 2008-11-26 EP disclosed
WO-2007102008-A1 THE USE OF BETA-AMINOALCOHOLS IN THE TREATMENT OF INFLAMMATORY DISORDERS AND PAIN SOSEI R & D LTD. (GB) 2007-09-13 WO disclosed