Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 9/20 | 0.62 |
| ▸ | PDE4A | P27815 | 5/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.61 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38656506 | 0.93 | PDE5A (0.72) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL12088079 | 0.85 | PDE5A (0.68) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9269452 | 0.84 | PDE5A (0.56) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL25711628 | 0.84 | PDE5A (0.60) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30835050 | 0.82 | PDE5A (0.70) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28286332 | 0.82 | PDE5A (0.70) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2310980 | 0.81 | ALDH1A1 (0.54) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18898887 | 0.80 | NPC1 (0.63) | PDE5AAMY1ANPC1ALDH1A1RAB9A | |
| SCHEMBL2096955 | 0.80 | AMY1A (0.58) | PDE5AAMY1ANPC1ALDH1A1RAB9A | |
| SCHEMBL31027930 | 0.80 | AMY1A (0.76) | PDE5AAMY1ANPC1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194981-B1 | BISBENZIMIDAZOLES AS ANTIMALARIAL AGENTS | UNIV MONS HAINAUT (BE) | 2011-11-23 | — | — | EP | disclosed |
| US-20100160402-A1 | Bisbenzimidazoles as antimalarial agents | XAVIER UNIVERSITY OF LOUISIANA | 2010-06-24 | — | — | US | disclosed |
| US-20100160402-A1 | Bisbenzimidazoles as antimalarial agents | XAVIER UNIVERSITY OF LOUISIANA | 2010-06-24 | — | — | US | disclosed |
| US-20100160402-A1 | Bisbenzimidazoles as antimalarial agents | XAVIER UNIVERSITY OF LOUISIANA | 2010-06-24 | — | — | US | disclosed |
| EP-2194981-A1 | BISBENZIMIDAZOLES AS ANTIMALARIAL AGENTS | Université de Mons-Hainaut (BE) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009043902-A1 | BISBENZIMIDAZOLES AS ANTIMALARIAL AGENTS | UNIVERSITE DE MONS HAINAUT (BE) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160402-A1 | Bisbenzimidazoles as antimalarial agents | NQO2, SQOR, CPS1 | PDE5A 4650/4885PDE4A 4482/4885PDE4B 4484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.