Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 8/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4654087 | 0.84 | SMN1; SMN2 (0.49) | MAPTHTTLTA4HCYP1A2CYP3A4 | |
| SCHEMBL4505988 | 0.77 | SMN1; SMN2 (0.50) | POLBLMNAMEN1ALDH1A1MAPT | |
| SCHEMBL4519178 | 0.76 | SMN1; SMN2 (0.40) | POLBLMNAMEN1ALDH1A1MAPT | |
| SCHEMBL4689887 | 0.76 | CYP1A2 (0.60) | LTA4HCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL3726328 | 0.76 | ACACB (0.40) | POLBCYP1A2CYP3A4MAPK1ALDH1A3 | |
| SCHEMBL3720760 | 0.75 | ALDH1A3 (0.45) | POLBKMT2ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL11013933 | 0.74 | PPARA (0.41) | LMNAMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL4516981 | 0.74 | SMN1; SMN2 (0.37) | POLBLMNAMEN1ALDH1A1MAPT | |
| SCHEMBL3719825 | 0.74 | ALDH1A1 (0.45) | LMNAMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL2622449 | 0.74 | SMN1; SMN2 (0.37) | POLBLMNAMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996567-A2 | NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME | ABBOTT LABORATORIES (US) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007095601-A2 | NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME | ABBOTT LABORATORIES (US) | 2007-08-23 | — | — | WO | disclosed |