SCHEMBL4656202

SCHEMBL4656202

O=C(Cc1ccccc1)C1CCC1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.56
HPGD P15428 2/20 0.56
USP2 O75604 1/20 0.56
FAAH O00519 1/20 0.56
GLA P06280 1/20 0.53
EPHX2 P34913 1/20 0.51
CES2 O00748 1/20 0.50
CES1 P23141 1/20 0.50
AKR1B1 P15121 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.49
MEN1 O00255 3/20 0.48
KMT2A Q03164 3/20 0.48
HDAC8 Q9BY41 1/20 0.48
HDAC6 Q9UBN7 1/20 0.48
LMNA P02545 1/20 0.47
CHRM2 P08172 1/20 0.46
CHRM3 P20309 1/20 0.46
KDM4E B2RXH2 1/20 0.45
POLB P06746 1/20 0.45
CYP2C19 P33261 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL800064 0.96 EPHX2 (0.56) ALDH1A1HPGDUSP2FAAHGLA
SCHEMBL163232 0.94 EPHX2 (0.59) ALDH1A1HPGDUSP2FAAHGLA
SCHEMBL1155730 0.92 FAAH (0.55) ALDH1A1HPGDUSP2FAAHGLA
SCHEMBL1477277 0.83 GBA1 (0.50) ALDH1A1HPGDFAAHGLAEPHX2
SCHEMBL4674087 0.83 FAAH (0.47) ALDH1A1HPGDUSP2FAAHGLA
SCHEMBL25813103 0.82 L3MBTL1 (0.47) ALDH1A1HPGDUSP2FAAHGLA
Hydrochloric Acid SCHEMBL9310454 0.82 GBA1 (0.49) ALDH1A1HPGDFAAHGLAEPHX2
SCHEMBL14036245 0.81 ALDH1A1 (0.56) ALDH1A1HPGDUSP2EPHX2L3MBTL1
SCHEMBL4384032 0.79 TAAR1 (0.53) ALDH1A1HPGDUSP2FAAHGLA
SCHEMBL6657922 0.79 ABL1 (0.68) FAAHMEN1KMT2ACHRM2CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1006122-B1 PHENETHYLAMINE DERIVATIVES CHUGAI PHARMACEUTICAL CO LTD (JP) 2008-12-03 EP claimed
US-6255285-B1 GASTROINTESTINAL DISORDERS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2001-07-03 US claimed
EP-1006122-A1 PHENETHYLAMINE DERIVATIVES CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2000-06-07 EP claimed
EP-0469887-B1 Acetamide derivatives ZENECA LTD (GB) 1994-12-14 EP claimed
EP-1006122-B1 PHENETHYLAMINE DERIVATIVES CHUGAI PHARMACEUTICAL CO LTD (JP) 2008-12-03 EP disclosed
US-6255285-B1 GASTROINTESTINAL DISORDERS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2001-07-03 US disclosed
EP-1006122-A1 PHENETHYLAMINE DERIVATIVES CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2000-06-07 EP disclosed
US-5430060-A Aldose reductase inhibitor ZENECA LIMITED (GB) 1995-07-04 US disclosed
US-5270342-A Acetamide derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-12-14 US disclosed