SCHEMBL4656265

SCHEMBL4656265

CN[C@@](C)(C(=O)O)c1cccs1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 1/20 0.40
MMP9 P14780 1/20 0.40
MMP13 P45452 1/20 0.40
TSHR P16473 1/20 0.39
DAO P14920 1/20 0.38
LMNA P02545 1/20 0.37
KMT2A Q03164 1/20 0.37
CYP2C19 P33261 1/20 0.37
ALDH1A1 P00352 2/20 0.36
HDAC1 Q13547 3/20 0.36
HDAC2 Q92769 2/20 0.36
CHRM3 P20309 3/20 0.36
CHRM2 P08172 2/20 0.36
CHRM1 P11229 2/20 0.36
KIF11 P52732 1/20 0.35
HDAC3 O15379 1/20 0.35
CES2 O00748 1/20 0.35
CES1 P23141 1/20 0.35
POLB P06746 2/20 0.35
GAA P10253 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4656263 1.00 MMP1 (0.40) MMP1MMP9MMP13TSHRDAO
SCHEMBL2477749 0.83 LMNA (0.39) MMP1MMP9MMP13TSHRDAO
SCHEMBL2477747 0.83 LMNA (0.39) MMP1MMP9MMP13TSHRDAO
SCHEMBL7775510 0.83 LMNA (0.39) MMP1MMP9MMP13TSHRDAO
SCHEMBL3553060 0.78 CTSK (0.44) LMNAKMT2AGAASMN1; SMN2CTSS
SCHEMBL4004775 0.78 CTSK (0.44) LMNAKMT2AGAASMN1; SMN2CTSS
SCHEMBL73588 0.77 DAO (0.43) TSHRDAOLMNAKMT2ACYP2C19
SCHEMBL1421302 0.77 DAO (0.43) TSHRDAOLMNAKMT2ACYP2C19
SCHEMBL7432298 0.77 DAO (0.43) TSHRDAOLMNAKMT2ACYP2C19
SCHEMBL599752 0.77 DAO (0.43) TSHRDAOLMNAKMT2ACYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1006122-B1 PHENETHYLAMINE DERIVATIVES CHUGAI PHARMACEUTICAL CO LTD (JP) 2008-12-03 EP claimed
EP-1006122-B1 PHENETHYLAMINE DERIVATIVES CHUGAI PHARMACEUTICAL CO LTD (JP) 2008-12-03 EP disclosed
US-6255285-B1 GASTROINTESTINAL DISORDERS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2001-07-03 US disclosed
CN-1272114-A Phenethylamine derivatives CHUGAI PHARMACEUTICAL CO LTD (JP) 2000-11-01 CN disclosed
EP-1006122-A1 PHENETHYLAMINE DERIVATIVES CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2000-06-07 EP disclosed