Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | MTNR1A | P48039 | 10/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 10/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4216627 | 1.00 | CYP1A2 (0.57) | CYP1A2MTNR1AMTNR1BCA1CA2 | |
| SCHEMBL4207460 | 0.86 | MTNR1A (0.47) | CYP1A2MTNR1AMTNR1BCA1CA2 | |
| SCHEMBL4517933 | 0.84 | MTNR1A (0.44) | CYP1A2MTNR1AMTNR1BCA1CA2 | |
| SCHEMBL4518508 | 0.82 | MTNR1A (0.44) | CYP1A2MTNR1AMTNR1BCA1CA2 | |
| SCHEMBL4514272 | 0.82 | MTNR1A (0.44) | CYP1A2MTNR1AMTNR1BCA1CA2 | |
| SCHEMBL4217159 | 0.81 | MTNR1A (0.73) | CYP1A2MTNR1AMTNR1BCA1CA2 | |
| SCHEMBL8960011 | 0.79 | MTNR1A (0.52) | CYP1A2MTNR1AMTNR1BCA1CA2 | |
| SCHEMBL4221230 | 0.79 | DRD4 (0.42) | CYP1A2MTNR1AMTNR1BCA1CA2 | |
| SCHEMBL7543096 | 0.78 | DRD2 (0.58) | CYP1A2MTNR1AMTNR1BCA1CA2 | |
| SCHEMBL4519458 | 0.78 | SMN1; SMN2 (0.51) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1999121-A1 | NOVEL TETRALINS AS 5-HT6 MODULATORS | AstraZeneca AB (SE) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007108742-A1 | NOVEL TETRALINS AS 5-HT6 MODULATORS | ASTRAZENECA AB (SE) | 2007-09-27 | — | — | WO | disclosed |