Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 4/20 | 0.45 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 6/20 | 0.42 |
| ▸ | CTSK | P43235 | 6/20 | 0.42 |
| ▸ | CTSB | P07858 | 3/20 | 0.42 |
| ▸ | CTSL | P07711 | 3/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4656413 | 0.91 | SYK (0.51) | SYKATMMAPTAPPCTSK | |
| SCHEMBL4657115 | 0.87 | ATM (0.51) | SYKATMAPPCTSSCTSK | |
| SCHEMBL6541785 | 0.87 | SYK (0.74) | SYKATMMAPTAPPCTRB1 | |
| SCHEMBL975349 | 0.87 | SYK (0.74) | SYKATMMAPTAPPCTRB1 | |
| SCHEMBL4657183 | 0.85 | CTSL (0.47) | SYKCTRB1CTSKCTSL | |
| SCHEMBL6310847 | 0.82 | SYK (0.82) | SYKATMMAPTAPPCTRB1 | |
| SCHEMBL6310853 | 0.82 | SYK (0.82) | SYKATMMAPTAPPCTRB1 | |
| SCHEMBL6310843 | 0.82 | SYK (0.82) | SYKATMMAPTAPPCTRB1 | |
| SCHEMBL14497009 | 0.80 | SYK (0.74) | SYKATMMAPTAPPCTRB1 | |
| SCHEMBL4657364 | 0.80 | ATM (0.46) | ATMAPPCTSSCTSKCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1006122-B1 | PHENETHYLAMINE DERIVATIVES | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2008-12-03 | — | — | EP | disclosed |
| US-6255285-B1 | GASTROINTESTINAL DISORDERS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-07-03 | — | — | US | disclosed |
| EP-1006122-A1 | PHENETHYLAMINE DERIVATIVES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-06-07 | — | — | EP | disclosed |