Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 4/20 | 0.39 |
| ▸ | CA2 | P00918 | 4/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM5A | P29375 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4657300 | 0.78 | L3MBTL1 (0.40) | CLK1DYRK1ACA1CA2NCOA3 | |
| SCHEMBL5166643 | 0.77 | CLK1 (0.40) | CLK1DYRK1ACA1CA2NCOA3 | |
| SCHEMBL5169185 | 0.77 | CLK1 (0.40) | CLK1DYRK1ACA1CA2NCOA3 | |
| SCHEMBL4657181 | 0.77 | ALDH1A1 (0.51) | CLK1DYRK1ACA1CA2NCOA3 | |
| SCHEMBL5184087 | 0.76 | CLK1 (0.39) | CLK1DYRK1ACA1CA2NCOA3 | |
| SCHEMBL4031840 | 0.75 | KDM4E (0.39) | CLK1DYRK1ACA1CA2NCOA3 | |
| SCHEMBL27779196 | 0.74 | MAPT (0.42) | CLK1DYRK1ANCOA3KDM4EALDH1A1 | |
| SCHEMBL6603195 | 0.73 | POLB (0.42) | KDM4EALDH1A1KDM5AGAAMEN1 | |
| SCHEMBL1920795 | 0.72 | ALDH1A1 (0.48) | CA1CA2KDM4EALDH1A1MEN1 | |
| SCHEMBL3245559 | 0.72 | CA1 (0.52) | CA1CA2KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549615-B1 | NAPHTHAMIDE DERIVATIVES AND THEIR USE | ASTRAZENECA AB (SE) | 2008-12-03 | — | — | EP | disclosed |