SCHEMBL4657409

SCHEMBL4657409

C[C](C)CCc1cccnc1

nearest known ligand 0.59

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 2/20 0.59
CYP19A1 P11511 2/20 0.59
CHRNA7 P36544 2/20 0.57
TDP1 Q9NUW8 1/20 0.56
L3MBTL1 Q9Y468 1/20 0.56
TBXAS1 P24557 8/20 0.54
CYP2A6 P11509 1/20 0.53
FDPS P14324 1/20 0.51
HRH1 P35367 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL868044 0.85 TBXAS1 (0.60) ESR1CYP19A1CHRNA7TDP1L3MBTL1
Hydrochloric Acid SCHEMBL11004443 0.83 TBXAS1 (0.61) ESR1CYP19A1CHRNA7TDP1L3MBTL1
SCHEMBL29294048 0.83 ESR1 (0.55) ESR1CYP19A1CHRNA7TDP1L3MBTL1
SCHEMBL724866 0.80 CHRNA7 (0.74) CHRNA7TDP1L3MBTL1TBXAS1CYP2A6
SCHEMBL29485692 0.80 CHRNA7 (0.74) CHRNA7TDP1L3MBTL1TBXAS1CYP2A6
SCHEMBL27939457 0.80 TBXAS1 (0.64) CHRNA7TDP1L3MBTL1TBXAS1CYP2A6
SCHEMBL7165228 0.79 TBXAS1 (0.68) ESR1CYP19A1CHRNA7TDP1L3MBTL1
SCHEMBL9522811 0.79 TDP1 (0.61) ESR1CYP19A1CHRNA7TDP1L3MBTL1
Lithium Ion SCHEMBL987070 0.79 TBXAS1 (0.58) ESR1CYP19A1CHRNA7TDP1L3MBTL1
Potassium Ion SCHEMBL27486991 0.79 TBXAS1 (0.58) ESR1CYP19A1CHRNA7TDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2001838-A2 SELECTIVE HYDROXAMATE BASED MMP INHIBITORS Novartis AG (CH) 2008-12-17 EP disclosed
WO-2007117981-A2 SELECTIVE HYDROXAMATE BASED MMP INHIBITORS NOVARTIS AG (CH) 2007-10-18 WO disclosed
EP-1129070-A4 NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS BRISTOL MYERS SQUIBB CO (US) 2005-03-02 EP disclosed
EP-1129070-A1 NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 2001-09-05 EP disclosed
WO-2000027811-A1 NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 2000-05-18 WO disclosed