Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11195264 | 0.81 | ALDH1A1 (0.83) | ALDH1A1POLBSMN1; SMN2KMT2AL3MBTL1 | |
| SCHEMBL11661567 | 0.80 | ALDH1A1 (0.87) | ALDH1A1POLBSMN1; SMN2KMT2AL3MBTL1 | |
| SCHEMBL4869922 | 0.79 | AVPR2 (0.46) | ALDH1A1POLBSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4458935 | 0.78 | NPSR1 (0.47) | ALDH1A1POLBKMT2AL3MBTL1MEN1 | |
| SCHEMBL28367062 | 0.77 | ALDH1A1 (0.62) | ALDH1A1POLBSMN1; SMN2KMT2AL3MBTL1 | |
| SCHEMBL398536 | 0.75 | NPSR1 (0.44) | ALDH1A1POLBKMT2AL3MBTL1MEN1 | |
| SCHEMBL6905225 | 0.75 | KMT2A (0.46) | ALDH1A1POLBKMT2AL3MBTL1MEN1 | |
| SCHEMBL3424139 | 0.74 | SMN1; SMN2 (0.44) | ALDH1A1POLBSMN1; SMN2KMT2AL3MBTL1 | |
| SCHEMBL7467929 | 0.74 | ALDH1A1 (0.77) | ALDH1A1POLBSMN1; SMN2KMT2AL3MBTL1 | |
| SCHEMBL402771 | 0.73 | NPSR1 (0.41) | ALDH1A1POLBKMT2AL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917258-A2 | PYRIMIDINYL-PYRAZOLE INHIBITORS OF AURORA KINASES | SmithKline Beecham Corporation (US) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007024843-A2 | PYRIMIDINYL-PYRAZOLE INHIBITORS OF AURORA KINASES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-01 | — | — | WO | disclosed |