Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 17/20 | 0.70 |
| ▸ | PPARA | Q07869 | 13/20 | 0.70 |
| ▸ | PPARD | Q03181 | 10/20 | 0.70 |
| ▸ | ACLY | P53396 | 2/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16486237 | 0.88 | PPARG (0.71) | PPARGPPARAPPARDACLY | |
| SCHEMBL16486365 | 0.86 | PPARG (0.73) | PPARGPPARAPPARDACLY | |
| SCHEMBL549089 | 0.84 | CA12 (0.51) | PPARGPPARAPPARDNOD2NOD1 | |
| SCHEMBL3562156 | 0.83 | PPARG (0.61) | PPARGPPARAPPARDACLYNOD2 | |
| SCHEMBL3520004 | 0.82 | PPARG (1.00) | PPARGPPARAPPARD | |
| SCHEMBL3525018 | 0.82 | PPARG (1.00) | PPARGPPARAPPARD | |
| SCHEMBL3519998 | 0.81 | PPARG (0.98) | PPARGPPARAPPARD | |
| SCHEMBL3527488 | 0.80 | PPARG (1.00) | PPARGPPARAPPARD | |
| SCHEMBL3520000 | 0.80 | PPARG (0.83) | PPARGPPARAPPARD | |
| SCHEMBL3522355 | 0.80 | PPARG (1.00) | PPARGPPARAPPARDACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100482223-C | As 5-HT6And/or 5-HT75-halo-tryptamine derivatives of ligands of 5-hydroxytryptamine receptors | SIGMA TAU INDUSTIE FARMACEUTI (IT) | 2009-04-29 | — | — | CN | disclosed |
| EP-1404317-B1 | 5-HALO-TRYPTAMINE DERIVATIVES USED AS LIGANDS OF THE 5-HT 6? AND/OR 5-HT 7? SEROTONIN RECEPTORS | SIGMA TAU IND FARMACEUTI (IT) | 2008-12-10 | — | — | EP | disclosed |
| US-7098233-B2 | 5-halo-tryptamine derivatives used as ligands on the 5-HT6 and/or 5-HT7 serotonin receptors | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2006-08-29 | — | — | US | disclosed |
| US-20040235899-A1 | 5-halo-tryptamine derivatives used as ligands of the 5-ht6 and/or 5-ht7 serotonin receptors | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2004-11-25 | — | — | US | disclosed |
| CN-1535146-A | 5-halo-tryptamine derivatives used as ligands of 5-HT 6 and/or 5-HT7 serotonin receptors | ϣ��������ҩ��ҵ��˾ | 2004-10-06 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235899-A1 | 5-halo-tryptamine derivatives used as ligands of the 5-ht6 and/or 5-ht7 serotonin receptors | HTR7, HTR6, HTR1A | PPARG 1880/4885PPARA 2380/4885PPARD 2036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.