Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 6/20 | 0.37 |
| ▸ | CCND1 | P24385 | 6/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.32 |
| ▸ | CDK2 | P24941 | 3/20 | 0.32 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.31 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974567 | 0.81 | MEN1 (0.39) | MEN1HPGDKMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL5344492 | 0.77 | LMNA (0.46) | KMT2AL3MBTL1 | |
| SCHEMBL7973868 | 0.73 | MEN1 (0.33) | MEN1HPGDKMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL16202074 | 0.71 | CNR1 (0.47) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16983104 | 0.70 | MAPK14 (0.41) | MEN1KMT2ACDK4CCND1 | |
| SCHEMBL16202077 | 0.70 | NOTUM (0.48) | L3MBTL1 | |
| SCHEMBL16202103 | 0.69 | MAPT (0.47) | MEN1HPGDKMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL14996591 | 0.68 | CYP1A2 (0.44) | MEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL18831455 | 0.66 | MEN1 (0.53) | MEN1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL20354130 | 0.65 | SETDB1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732541-A4 | CYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL (JP) | 2008-03-05 | — | — | EP | disclosed |
| EP-1732541-A2 | CYCLIC COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005099688-A2 | CYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-10-27 | — | — | WO | disclosed |