Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 4/20 | 0.35 |
| ▸ | CCND1 | P24385 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.31 |
| ▸ | CDK2 | P24941 | 3/20 | 0.31 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6978060 | 0.82 | GABRA2 (0.50) | — | |
| SCHEMBL4658013 | 0.81 | MEN1 (0.41) | MEN1HPGDKMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL6963756 | 0.75 | SRC (0.35) | KDRSRCBRAF | |
| SCHEMBL16202103 | 0.67 | MAPT (0.47) | MEN1HPGDKMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL6967743 | 0.66 | GABRP (0.48) | MEN1HPGDKMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL5344492 | 0.63 | LMNA (0.46) | KMT2AL3MBTL1OPRM1LMNAOPRD1 | |
| SCHEMBL9780177 | 0.62 | GABRA2 (0.50) | — | |
| SCHEMBL10370302 | 0.62 | MEN1 (0.47) | MEN1HPGDKMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL23130243 | 0.62 | NPC1 (0.42) | MEN1KMT2ASMN1; SMN2KDRSRC | |
| SCHEMBL5826687 | 0.62 | KDR (0.54) | MEN1HPGDKMT2ASMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946515-B1 | PARASITICIDAL PYRAZOLES | PFIZER LTD (GB) | 2003-03-05 | — | — | EP | disclosed |
| US-6268509-B1 | PESTICIDES | PFIZER INC | 2001-07-31 | — | — | US | disclosed |
| US-6075043-A | Parasiticidal pyrazoles | PFIZER INC. (US) | 2000-06-13 | — | — | US | disclosed |