Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL27547420 | 0.98 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1AKR1C3GLA | |
| Styrene SCHEMBL385100 | 0.95 | ALDH1A1 (0.70) | ALDH1A1TSHRTDP1AKR1C3GLA | |
| Styrene SCHEMBL27318228 | 0.93 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1AKR1C3GLA | |
| Styrene SCHEMBL28284709 | 0.91 | ALDH1A1 (0.64) | ALDH1A1TSHRTDP1AKR1C3GLA | |
| Styrene SCHEMBL8348522 | 0.91 | ALDH1A1 (0.64) | ALDH1A1TSHRTDP1AKR1C3GLA | |
| Styrene SCHEMBL5858997 | 0.91 | ALDH1A1 (0.70) | ALDH1A1TSHRTDP1AKR1C3GLA | |
| Styrene SCHEMBL10614939 | 0.91 | ALDH1A1 (0.70) | ALDH1A1TSHRTDP1AKR1C3GLA | |
| Styrene SCHEMBL19281746 | 0.89 | ALDH1A1 (0.61) | ALDH1A1TSHRTDP1AKR1C3GLA | |
| Styrene SCHEMBL6697336 | 0.88 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1AKR1C3GLA | |
| Styrene SCHEMBL27529933 | 0.88 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1AKR1C3GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349639-B1 | METHOD OF SEPARATING ISOTOPES | AREVA NP (FR) | 2008-12-03 | — | — | EP | claimed |