Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.60 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10500771 | 1.00 | PRMT5 (0.60) | PRMT5WDR77KMT2AMEN1ACHE | |
| SCHEMBL3901109 | 1.00 | PRMT5 (0.60) | PRMT5WDR77KMT2AMEN1ACHE | |
| SCHEMBL27568731 | 0.87 | PRMT5 (0.58) | PRMT5WDR77KMT2AMEN1ACHE | |
| SCHEMBL27548998 | 0.87 | PRMT5 (0.58) | PRMT5WDR77KMT2AMEN1ACHE | |
| SCHEMBL9304736 | 0.84 | PRMT5 (0.44) | PRMT5WDR77KMT2AMEN1ACHE | |
| SCHEMBL9546855 | 0.84 | PRMT5 (0.44) | PRMT5WDR77KMT2AMEN1ACHE | |
| SCHEMBL7470093 | 0.82 | PRMT5 (0.67) | PRMT5WDR77KMT2AMEN1PKM | |
| SCHEMBL7480912 | 0.82 | PRMT5 (0.76) | PRMT5WDR77KMT2AMEN1ACHE | |
| SCHEMBL7537706 | 0.81 | LMNA (0.47) | PRMT5WDR77KMT2AMEN1ACHE | |
| SCHEMBL8115571 | 0.79 | PRMT5 (0.51) | PRMT5WDR77KMT2AMEN1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720855-A4 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORP (US) | 2008-12-17 | — | — | EP | disclosed |
| US-20070185152-A1 | Inhibitors of akt activity | SMITHKLINE BEECHAM CORPORATION | 2007-08-09 | — | — | US | disclosed |
| EP-1720855-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005085227-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2005-09-15 | — | — | WO | disclosed |
| EP-0157623-B1 | OPTICALLY ACTIVE ISOMERS OF BENZOPYRAN DERIVATIVES USEFUL FOR TREATING CARDIOVASCULAR DISEASE | KOWA COMPANY, LTD. (JP) | 1989-03-22 | — | — | EP | disclosed |
| US-4678803-A | CARDIOVASCULAR DISORDERS | KOWA COMPANY, LTD. (JP) | 1987-07-07 | — | — | US | disclosed |
| EP-0157623-A2 | Optically active isomers of benzopyran derivatives useful for treating cardiovascular disease | KOWA COMPANY, LTD. (JP) | 1985-10-09 | — | — | EP | disclosed |
| EP-0071251-B1 | NOVEL AMINOGLYCOSIDES AND USE THEREOF | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1985-04-24 | — | — | EP | disclosed |
| US-4438107-A | Aminoglycosides and use thereof | KOWA COMPANY, LTD. (JP) | 1984-03-20 | — | — | US | disclosed |
| EP-0071251-A1 | Novel aminoglycosides and use thereof | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1983-02-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185152-A1 | Inhibitors of akt activity | AKT1, AKT1S1, AKT2 | PRMT5 2284/4885WDR77 2278/4885KMT2A 1897/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.