Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.76 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL336605 | 0.87 | PRMT5 (1.00) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL336603 | 0.87 | PRMT5 (1.00) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL449928 | 0.87 | PRMT5 (1.00) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL30301224 | 0.87 | PRMT5 (1.00) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL29481767 | 0.87 | PRMT5 (1.00) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL29476299 | 0.87 | PRMT5 (1.00) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL4658490 | 0.82 | PRMT5 (0.60) | PRMT5WDR77KMT2ACA2MMP2 | |
| SCHEMBL3901109 | 0.82 | PRMT5 (0.60) | PRMT5WDR77KMT2ACA2MMP2 | |
| SCHEMBL10500771 | 0.82 | PRMT5 (0.60) | PRMT5WDR77KMT2ACA2MMP2 | |
| SCHEMBL7727416 | 0.78 | PRMT5 (0.77) | PRMT5WDR77KMT2AGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192157-A1 | BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000077000-A1 | NEW BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2000-12-21 | — | — | WO | disclosed |