Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.52 |
| ▸ | MMP13 | P45452 | 2/20 | 0.52 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | PRKCG | P05129 | 1/20 | 0.52 |
| ▸ | PRKACA | P17612 | 1/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | AKT1 | P31749 | 1/20 | 0.52 |
| ▸ | GSK3A | P49840 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | PRKX | P51817 | 1/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.52 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.52 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1568699 | 0.84 | NAMPT (0.69) | KMT2AL3MBTL1ROCK2ROCK1MMP13 | |
| SCHEMBL27833527 | 0.83 | KMT2A (0.70) | KMT2AL3MBTL1ROCK2ROCK1MMP13 | |
| SCHEMBL1568246 | 0.81 | SMN1; SMN2 (0.68) | KMT2AL3MBTL1ROCK2MAPK1RAB9A | |
| SCHEMBL30780061 | 0.81 | HPGD (0.77) | KMT2AL3MBTL1ROCK2ROCK1MMP13 | |
| SCHEMBL1568387 | 0.81 | HPGD (0.77) | KMT2AL3MBTL1ROCK2ROCK1MMP13 | |
| SCHEMBL6779494 | 0.79 | KMT2A (0.65) | KMT2AL3MBTL1ROCK2ROCK1MMP13 | |
| SCHEMBL27833534 | 0.78 | KMT2A (0.63) | KMT2AROCK2ROCK1MMP13RPS6KA5 | |
| SCHEMBL1568381 | 0.78 | HDAC1 (0.72) | KMT2AROCK2ROCK1ALDH1A1HPGD | |
| SCHEMBL1569194 | 0.77 | ROCK2 (0.82) | KMT2AL3MBTL1ROCK2ROCK1MMP13 | |
| SCHEMBL27913635 | 0.75 | KMT2A (0.56) | KMT2AL3MBTL1ROCK2PRKCGPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001851-A2 | AMIDE DERIVATIVES AND THEIR APPLICATION FOR THE TREAMENT OF G PROTEIN RELATED DISEASES | Novartis AG (CH) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007110237-A2 | AMIDE DERIVATIVES AND THEIR APPLICATION FOR THE TREATMENT OF G PROTEIN RELATED DISEASES | NOVARTIS AG (CH) | 2007-10-04 | — | — | WO | disclosed |