SCHEMBL4658983

SCHEMBL4658983

O=C(O)n1c(C(F)(F)F)nc2cc(Br)c(Cl)cc21

nearest known ligand 0.36

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
KMT2A Q03164 2/20 0.34
MEN1 O00255 1/20 0.34
NT5E P21589 1/20 0.33
PPARG P37231 2/20 0.32
RXRA P19793 1/20 0.31
KMO O15229 1/20 0.30
TTR P02766 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11768622 0.90 CYP1A2 (0.36) CYP1A2CYP2D6CYP2C9CYP2C19KMT2A
SCHEMBL4660132 0.81 ALDH1A1 (0.40) CYP1A2CYP2D6CYP2C9CYP2C19KMT2A
SCHEMBL4660245 0.72
SCHEMBL118829 0.71 ALDH1A1 (0.45) CYP1A2CYP2D6CYP2C9CYP2C19KMT2A
SCHEMBL11510726 0.70 ALDH1A1 (0.38) CYP1A2CYP2D6CYP2C9CYP2C19KMT2A
SCHEMBL6738861 0.68 GAA (0.43) KMT2AMEN1
SCHEMBL11482358 0.66 CYP1A2 (0.33) CYP1A2CYP2C9
SCHEMBL22631398 0.66 KRAS (0.49) KMT2AMEN1
SCHEMBL6742556 0.64 PKM (0.48) KMT2AMEN1
SCHEMBL11685572 0.62 PPARG (0.34) KMT2AMEN1PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0981626-B1 FUNGICIDAL TEST METHOD BAYER CROPSCIENCE LTD (GB) 2008-12-17 EP claimed