SCHEMBL4659042

SCHEMBL4659042

CC(C)N(c1cccc(CCCc2cc(CO)ccc2OC(=O)c2ccc(Cl)cc2)c1)C(C)C

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.35
KMT2A Q03164 4/20 0.35
CNR1 P21554 1/20 0.34
NPC1 O15118 3/20 0.34
HTT P42858 3/20 0.34
RAB9A P51151 3/20 0.34
SMN1; SMN2 Q16637 3/20 0.34
TP53 P04637 2/20 0.34
GAA P10253 2/20 0.34
XBP1 P17861 1/20 0.34
HSD17B10 Q99714 1/20 0.34
CHRM2 P08172 1/20 0.34
CHRM1 P11229 1/20 0.34
ALDH1A1 P00352 2/20 0.33
CYP2C9 P11712 2/20 0.33
CYP2C19 P33261 2/20 0.33
HTR2C P28335 1/20 0.33
AKT1 P31749 1/20 0.33
CYP4F2 P78329 1/20 0.33
CYP4A11 Q02928 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4660356 0.91 ESR1 (0.35) KMT2ANPC1RAB9ASMN1; SMN2CHRM2
SCHEMBL4659041 0.91 CHRM2 (0.39) MAPTKMT2ANPC1HTTRAB9A
SCHEMBL4660361 0.90 KMT2A (0.39) KMT2ANPC1RAB9AALDH1A1L3MBTL1
SCHEMBL4659056 0.87 ALOX5 (0.41) MAPTKMT2ASMN1; SMN2ALDH1A1MEN1
SCHEMBL4661601 0.87 KDM4E (0.37) MAPTHTTCHRM2CHRM1HTR2C
SCHEMBL1158253 0.86 CHRM2 (0.45) CHRM2CHRM1AKT1CYP4F2CYP4A11
Hydrochloric Acid SCHEMBL16166428 0.85 CHRM2 (0.45) CHRM2CHRM1AKT1CYP4F2CYP4A11
SCHEMBL11297469 0.83 CHRM2 (0.35) CHRM2CHRM1AKT1CYP4F2CYP4A11
SCHEMBL4661559 0.83 ALOX15 (0.41) CHRM2CHRM1
SCHEMBL7755059 0.83 ELANE (0.44) CHRM2CHRM1ALDH1A1LMNAELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2004592-A1 SYNTHESIS OF PHENOLIC ESTERS OF HYDROXYMETHYL PHENOLS Schwarz Pharma Ltd. (IE) 2008-12-24 EP disclosed
WO-2007140986-A1 SYNTHESIS OF PHENOLIC ESTERS OF HYDROXYMETHYL PHENOLS SCHWARZ PHARMA LTD (IE) 2007-12-13 WO disclosed