SCHEMBL4659049

SCHEMBL4659049

CCCS(=O)(=O)N1CCC(C(CCC(=O)c2ncco2)C(CCC2CCN(S(=O)(=O)C(C)C)CC2)C(=O)c2ncco2)CC1

nearest known ligand 0.62

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
FAAH O00519 20/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4184172 0.78 FAAH (0.74) FAAH
SCHEMBL4184168 0.77 FAAH (1.00) FAAH
SCHEMBL4189326 0.74 FAAH (0.72) FAAH
SCHEMBL4659078 0.73 FAAH (0.46) FAAH
SCHEMBL4660305 0.71 FAAH (0.56) FAAH
SCHEMBL4659214 0.69 FAAH (0.55) FAAH
SCHEMBL4660422 0.69 FAAH (0.62) FAAH
SCHEMBL4195962 0.66 FAAH (1.00) FAAH
SCHEMBL4189653 0.66 FAAH (1.00) FAAH
SCHEMBL4179595 0.64 FAAH (1.00) FAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1954137-A4 2-KETO-OXAZOLES AS MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2008-12-17 EP claimed
EP-1954137-A2 2-KETO-OXAZOLES AS MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA N.V. (BE) 2008-08-13 EP claimed
WO-2007061862-A2 2-KETO-OXAZOLES AS MODULATORS OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA N.V. (BE) 2007-05-31 WO claimed