Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29495264 | 0.86 | ALDH1A1 (0.52) | SMN1; SMN2KMT2APOLBMEN1ALDH1A1 | |
| SCHEMBL28722474 | 0.86 | ALDH1A1 (0.52) | SMN1; SMN2KMT2APOLBMEN1ALDH1A1 | |
| SCHEMBL14397720 | 0.86 | KMT2A (0.54) | SMN1; SMN2KMT2APOLBMEN1ALDH1A1 | |
| SCHEMBL4791655 | 0.79 | HTR2A (0.48) | SMN1; SMN2KMT2APOLBMEN1ALDH1A1 | |
| SCHEMBL4768514 | 0.77 | HTR2A (0.49) | SMN1; SMN2KMT2APOLBMEN1ALDH1A1 | |
| SCHEMBL3386044 | 0.77 | ALDH1A1 (0.54) | SMN1; SMN2KMT2APOLBMEN1ALDH1A1 | |
| SCHEMBL28507375 | 0.76 | CYP2D6 (0.54) | SMN1; SMN2KMT2APOLBMEN1ALDH1A1 | |
| SCHEMBL14398264 | 0.74 | LTA4H (0.51) | SMN1; SMN2KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL519451 | 0.73 | LTA4H (0.71) | SMN1; SMN2ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL6996148 | 0.73 | KMT2A (0.56) | SMN1; SMN2KMT2APOLBMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004627-A2 | 3-PYRIDINYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007120600-A2 | 3-PYRIDINYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | disclosed |