Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4661587 | 0.93 | ESR1 (0.45) | ESR1ESR2L3MBTL1MEN1KMT2A | |
| SCHEMBL4662804 | 0.85 | ALDH1A1 (0.45) | ESR1ESR2MEN1KMT2AKDM4E | |
| SCHEMBL4660171 | 0.84 | MEN1 (0.42) | ESR1ESR2MEN1KMT2AKDM4E | |
| SCHEMBL4659954 | 0.83 | ESR1 (0.45) | ESR1ESR2L3MBTL1MEN1KMT2A | |
| SCHEMBL6433797 | 0.83 | ESR1 (0.45) | ESR1ESR2L3MBTL1MEN1KMT2A | |
| SCHEMBL4662613 | 0.83 | ESR1 (0.45) | ESR1ESR2L3MBTL1MEN1KMT2A | |
| SCHEMBL4659952 | 0.83 | ESR1 (0.45) | ESR1ESR2L3MBTL1MEN1KMT2A | |
| SCHEMBL5686369 | 0.82 | ESR1 (0.44) | ESR1ESR2L3MBTL1MEN1KMT2A | |
| SCHEMBL4660129 | 0.82 | ESR1 (0.44) | ESR1ESR2L3MBTL1MEN1KMT2A | |
| SCHEMBL4660125 | 0.82 | ESR1 (0.41) | ESR1ESR2L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620102-B1 | 3-(1-NAPHTHYL)-2-CYANOPROPANOIC ACID DERIVATIVES AS ESTROGEN RECEPTOR LIGANDS | WYETH CORP (US) | 2008-12-24 | — | — | EP | claimed |