Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspirin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.67 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | HPGD | P15428 | 6/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.67 |
| ▸ | ESR1 | P03372 | 1/20 | 0.67 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.67 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.67 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.67 |
| ▸ | GGT1 | P19440 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspirin SCHEMBL11063386 | 0.89 | KMT2A (0.58) | HSD17B10KDM4EALDH1A1HPGDTSHR | |
| Benorilate SCHEMBL1162333 | 0.85 | HSD17B10 (0.68) | HSD17B10KDM4EALDH1A1HPGDTSHR | |
| Aspirin SCHEMBL10380307 | 0.83 | KMT2A (0.63) | HSD17B10KDM4EALDH1A1HPGDTSHR | |
| Aspirin SCHEMBL20770305 | 0.83 | KMT2A (0.56) | HSD17B10KDM4EALDH1A1HPGDTSHR | |
| Aspirin SCHEMBL1353 | 0.82 | KDM4E (1.00) | HSD17B10KDM4EALDH1A1HPGDTSHR | |
| Aspirin SCHEMBL1331740 | 0.82 | KDM4E (1.00) | HSD17B10KDM4EALDH1A1HPGDTSHR | |
| Aspirin SCHEMBL10456693 | 0.82 | KDM4E (1.00) | HSD17B10KDM4EALDH1A1HPGDTSHR | |
| Aspirin SCHEMBL29350479 | 0.82 | KDM4E (1.00) | HSD17B10KDM4EALDH1A1HPGDTSHR | |
| Aspirin SCHEMBL7580 | 0.82 | KDM4E (1.00) | HSD17B10KDM4EALDH1A1HPGDTSHR | |
| Aspirin SCHEMBL4588777 | 0.81 | KDM4E (0.73) | HSD17B10KDM4EALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3461475-A1 | PHARMACEUTICAL COMPOSITION CONTAINING SYMPATHOMIMETIC AMINE SALT AND CO-DISTILLABLE ADDITIVE | Wyeth LLC (US) | 2019-04-03 | — | — | EP | claimed |
| EP-2004147-B1 | PHARMACEUTICAL COMPOSITION CONTAINING SYMPATHOMIMETIC AMINE SALT AND CO-DISTILLABLE ADDITIVE | WYETH LLC (US) | 2019-01-02 | — | — | EP | claimed |
| US-9238073-B2 | Pharmaceutical composition containing sympathomimetic amine salt and co-distillable additive | WYETH LLC (US) | 2016-01-19 | — | — | US | claimed |
| EP-2004147-A2 | PHARMACEUTICAL COMPOSITION CONTAINING SYMPATHOMIMETIC AMINE SALT AND CO-DISTILLABLE ADDITIVE | Wyeth a Corporation of the State of Delaware (US) | 2008-12-24 | — | — | EP | claimed |
| WO-2007120725-A2 | PHARMACEUTICAL COMPOSITION CONTAINING SYMPATHOMIMETIC AMINE SALT AND CO-DISTILLABLE ADDITIVE | WYETH (US) | 2007-10-25 | — | — | WO | claimed |
| US-20070243140-A1 | Pharmaceutical composition containing sympathomimetic amine salt and co-distillable additive | HALEON US HOLDINGS LLC | 2007-10-18 | — | — | US | claimed |
| US-20230241282-A1 | FOAM COMPOSITIONS, FOAM MATRICES AND METHODS | COVALON TECHNOLOGIES INC. (CA) | 2023-08-03 | — | — | US | disclosed |
| US-11517644-B2 | Foam compositions, foam matrices and methods | COVALON TECHNOLOGIES INC. (CA) | 2022-12-06 | — | — | US | disclosed |
| EP-3873991-A1 | FOAM COMPOSITIONS, FOAM MATRICES AND METHODS | Covalon Technologies Inc. (CA) | 2021-09-08 | — | — | EP | disclosed |
| US-20200139002-A1 | FOAM COMPOSITIONS, FOAM MATRICES AND METHODS | COVALON TECHNOLOGIES INC. (CA) | 2020-05-07 | — | — | US | disclosed |
| EP-2482223-B1 | Optical imager and method for correlating a medication package with a patient | METROLOGIC INSTR INC (US) | 2019-03-13 | — | — | EP | disclosed |
| US-9339475-B2 | Spatial arrangement of particles in a drinking device for oral delivery of pharmaceuticals | PARTICLE DYNAMICS INTERNATIONAL, LLC (US) | 2016-05-17 | — | — | US | disclosed |
| US-8942480-B2 | Optical imager and method for correlating a medication package with a patient | METROLOGIC INSTRUMENTS, INC. (US) | 2015-01-27 | — | — | US | disclosed |
| US-4894233-A | Novel drug delivery system for decongestants | CADBURY ADAMS USA LLC | 1990-01-16 | — | — | US | disclosed |
| US-4797288-A | Novel drug delivery system | WARNER-LAMBERT COMPANY (US) | 1989-01-10 | — | — | US | disclosed |
| US-4790991-A | CHOLESTYRAMINE TREATED WITH HYDROCOLLOID YIELDS PARTICLES WITH IMPROVED TASTE AND MOUTHFEEL; ANTICHOLESTEROL AGENTS | WARNER-LAMBERT COMPANY (US) | 1988-12-13 | — | — | US | disclosed |
| US-4747881-A | Ingestible aggregate and delivery system prepared therefrom | WARNER-LAMBERT COMPANY (US) | 1988-05-31 | — | — | US | disclosed |
| EP-0190826-A2 | Ingestible aggregate and delivery system incorporating the same | WARNER-LAMBERT COMPANY (US) | 1986-08-13 | — | — | EP | disclosed |
| EP-0177368-A2 | A novel drug delivery system and method of preparation thereof | WARNER-LAMBERT COMPANY (US) | 1986-04-09 | — | — | EP | disclosed |
| EP-0006845-B1 | PHARMACEUTICAL COMPOSITION COMPRISING A 5-AROYL-1-C1-5 ALKYL-PYRROLE-2-ACETIC ACID COMPOUND AND ACETAMINOPHEN OR ACETYLSALICYLIC ACID | McNeilab, Inc. (US) | 1982-02-03 | — | — | EP | disclosed |