Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspirin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.58 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.63 |
| ▸ | MEN1 | O00255 | 6/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.58 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.58 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.58 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | GGT1 | P19440 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspirin SCHEMBL11063386 | 0.95 | KMT2A (0.58) | KMT2AMEN1LMNATDP1CYP1A2 | |
| Aspirin SCHEMBL20770305 | 0.89 | KMT2A (0.56) | KMT2AMEN1LMNATDP1CYP1A2 | |
| Aspirin SCHEMBL11224110 | 0.89 | KDM4E (0.53) | KMT2AMEN1LMNATDP1CYP1A2 | |
| Benorilate SCHEMBL1162333 | 0.85 | HSD17B10 (0.68) | KMT2AMEN1LMNATDP1CYP1A2 | |
| Aspirin SCHEMBL4660338 | 0.83 | HSD17B10 (0.67) | KMT2AMEN1LMNATDP1CYP1A2 | |
| Phenacetin SCHEMBL27622268 | 0.83 | KMT2A (0.87) | KMT2AMEN1LMNATDP1CYP1A2 | |
| Phenacetin SCHEMBL28124259 | 0.80 | KMT2A (0.93) | KMT2AMEN1LMNATDP1CYP1A2 | |
| Phenacetin SCHEMBL23280 | 0.80 | KMT2A (1.00) | KMT2AMEN1LMNATDP1CYP1A2 | |
| Phenacetin SCHEMBL18894356 | 0.80 | KMT2A (1.00) | KMT2AMEN1LMNATDP1CYP1A2 | |
| Etersalate SCHEMBL24764 | 0.80 | ALDH1A1 (0.51) | KMT2AMEN1LMNATDP1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102988372-B | Screening and composition of main auxiliary materials of compound aspirin tablet, and preparation method of compound aspirin sheet | 广东九明制药有限公司 | 2017-05-03 | — | — | CN | claimed |
| CN-102988372-A | Screening and composition of main auxiliary materials of compound aspirin tablet, and preparation method of compound aspirin sheet | GUANGDONG JIUMING PHARMACEUTICAL CO LTD | 2013-03-27 | — | — | CN | claimed |
| CN-101301296-A | Compound preparation for treating beriberi and production method | BAOGUO DAI (CN) | 2008-11-12 | — | — | CN | claimed |
| CN-102988372-B | Screening and composition of main auxiliary materials of compound aspirin tablet, and preparation method of compound aspirin sheet | 广东九明制药有限公司 | 2017-05-03 | — | — | CN | disclosed |
| CN-103191135-B | The compositions of aspirin, phenacetin and caffeine tablet and preparation technology thereof | 广东九明制药有限公司 | 2016-06-22 | — | — | CN | disclosed |
| CN-105687151-A | Method for preparing tablet medicine on basis of ink-jet 3D printing technology | 西北工业大学 | 2016-06-22 | — | — | CN | disclosed |
| CN-105560554-A | Traditional Chinese medicine composition for diminishing inflammation and relieving sore throat and preparation method thereof | GUANGXI WUZHOU PHARMACEUTICAL (GROUP) CO LTD | 2016-05-11 | — | — | CN | disclosed |
| CN-104825857-A | Traditional Chinese medicine preparation used for treating child suppurative tonsillitis, and preparation method thereof | WANG XUEYAN | 2015-08-12 | — | — | CN | disclosed |
| CN-103191135-A | Acetylsalicylic acid-phenacetin-caffeine sheet composition and preparation technology thereof | GUANGDONG JIUMING PHARMACEUTICAL CO LTD | 2013-07-10 | — | — | CN | disclosed |
| CN-102138953-B | Application of chorispora bungeana or extract thereof in preparation of medicaments for preventing and treating cardiovascular and cerebrovascular diseases | UNIV LANGZHOU | 2013-04-17 | — | — | CN | disclosed |
| CN-102988372-A | Screening and composition of main auxiliary materials of compound aspirin tablet, and preparation method of compound aspirin sheet | GUANGDONG JIUMING PHARMACEUTICAL CO LTD | 2013-03-27 | — | — | CN | disclosed |
| CN-101897709-A | Drug composition containing small dosage of folic acid and aspirin and application thereof | BEIJING AOSA PHARMED RES CT CO LTD | 2010-12-01 | — | — | CN | disclosed |
| CN-101647867-A | Traditional Chinese medicine composition for clearing away heat and toxic material | CHONGQING STAR LAKE PHARMACEUT | 2010-02-17 | — | — | CN | disclosed |
| CN-1270742-C | Antiseptic Chinese medicine composition and its prepn process | SHANGHAI HAITIAN MEDICINE SCI (CN) | 2006-08-23 | — | — | CN | disclosed |
| CN-1651085-A | Compound aspirin tading kind medicinal preparation and its application | FUKANGREN BIOPHARM SCI & RES (CN) | 2005-08-10 | — | — | CN | disclosed |
| CN-1651042-A | Compound aspirin red yeast extract medicinal preparation and its application | BEIJING FUKANGREN BIO PHARMACE (CN) | 2005-08-10 | — | — | CN | disclosed |
| CN-1615892-A | Prescription of compound antipyretic analgesic containing etenzamide and its preparing method | LI JIE (CN) | 2005-05-18 | — | — | CN | disclosed |
| CN-1608648-A | Antiseptic Chinese medicine composition and its prepn process | SHANGHAI HAITIAN MEDICINE SCI (CN) | 2005-04-27 | — | — | CN | disclosed |
| WO-1990015593-A1 | A PROCESS FOR THE PREPARATION OF DRUG PARTICLES | YTKEMISKA INSTITUTET (SE) | 1990-12-27 | — | — | WO | disclosed |
| WO-1987005941-A1 | MICROCHEMILUMINESCENT ASSAY FOR DETECTION AND QUANTIFICATION OF OXIDATIVE INJURY TO CELLS | MCLAS TECHNOLOGIES, INC. (US) | 1987-10-08 | — | — | WO | disclosed |