Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 8/20 | 0.56 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4659078 | 0.79 | FAAH (0.46) | FAAH | |
| SCHEMBL4659119 | 0.73 | FAAH (0.56) | FAAHALDH1A1 | |
| SCHEMBL4195962 | 0.72 | FAAH (1.00) | FAAH | |
| SCHEMBL4724280 | 0.70 | FAAH (0.57) | FAAH | |
| SCHEMBL4182545 | 0.69 | FAAH (0.81) | FAAH | |
| SCHEMBL4659170 | 0.69 | FAAH (0.49) | FAAH | |
| SCHEMBL4719219 | 0.68 | FAAH (0.48) | FAAHMEN1KMT2AALDH1A1PKM | |
| SCHEMBL4189635 | 0.66 | FAAH (1.00) | FAAH | |
| SCHEMBL4659075 | 0.66 | FAAH (0.44) | FAAH | |
| SCHEMBL4179595 | 0.64 | FAAH (1.00) | FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954137-A4 | 2-KETO-OXAZOLES AS MODULATORS OF FATTY ACID AMIDE HYDROLASE | JANSSEN PHARMACEUTICA NV (BE) | 2008-12-17 | — | — | EP | claimed |
| EP-1954137-A2 | 2-KETO-OXAZOLES AS MODULATORS OF FATTY ACID AMIDE HYDROLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-13 | — | — | EP | claimed |
| WO-2007061862-A2 | 2-KETO-OXAZOLES AS MODULATORS OF FATTY ACID AMIDE HYDROLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-31 | — | — | WO | claimed |