SCHEMBL46608

SCHEMBL46608

O=S(=O)(O)c1cc(Nc2nc(Cl)nc(Cl)n2)ccc1/C=C/c1ccc(Nc2nc(Cl)nc(Cl)n2)cc1S(=O)(=O)O

nearest known ligand 0.49

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ENPP2 Q13822 2/20 0.49
CA12 O43570 6/20 0.48
CA1 P00915 6/20 0.48
CA2 P00918 6/20 0.48
CA9 Q16790 6/20 0.48
CA14 Q9ULX7 1/20 0.48
CHAT P28329 3/20 0.43
USP2 O75604 1/20 0.43
APEX1 P27695 1/20 0.43
HPGDS O60760 1/20 0.43
NFKB1 P19838 3/20 0.42
ENPP3 O14638 1/20 0.42
ENPP1 P22413 1/20 0.42
POLB P06746 1/20 0.41
TERT O14746 1/20 0.40
TXN P10599 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2204687 1.00 ENPP2 (0.49) ENPP2CA12CA1CA2CA9
SCHEMBL11732259 0.99 ENPP2 (0.48) ENPP2CA12CA1CA2CA9
SCHEMBL2220503 0.99 ENPP2 (0.48) ENPP2CA12CA1CA2CA9
Calcium SCHEMBL2206379 0.99 ENPP2 (0.48) ENPP2CA12CA1CA2CA9
SCHEMBL2220482 0.97 ENPP2 (0.47) ENPP2CA12CA1CA2CA9
SCHEMBL16258799 0.95 ENPP2 (0.45) ENPP2CA12CA1CA2CA9
SCHEMBL16258775 0.94 ENPP2 (0.44) ENPP2CA12CA1CA2CA9
SCHEMBL15258072 0.93 ENPP2 (0.46) ENPP2CA12CA1CA2CA9
SCHEMBL2205601 0.92 CA12 (0.47) ENPP2CA12CA1CA2CA9
SCHEMBL18043806 0.92 CA12 (0.47) ENPP2CA12CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2571973-B1 OPTICAL BRIGHTENERS AND COMPOSITIONS COMPRISING THE SAME MILLIKEN & CO (US) 2020-04-01 EP disclosed
EP-2716466-B1 THERMAL RECORDING MATERIAL CONTAINING STILBENE DISULPHONIC ACID FLUORESCENT WHITENING AGENT RICOH IND FRANCE SAS (FR) 2016-09-14 EP disclosed
US-9376405-B2 Bis-(triazinylamino)-stilbene derivatives CLARIANT INTERNATIONAL LTD (CH) 2016-06-28 US disclosed
EP-2518058-B1 Novel bis-(triazinylamino)-stilbene derivatives CLARIANT INT LTD (CH) 2014-10-29 EP disclosed
US-8740997-B2 Optical brighteners and compositions comprising the same MILLIKEN & COMPANY (US) 2014-06-03 US disclosed
US-20140142305-A1 NOVEL BIS-(TRIAZINYLAMINO)-STILBENE DERIVATIVES CLARIANT INTERNATIONAL LTD (CH) 2014-05-22 US disclosed
US-20130281347-A1 OPTICAL BRIGHTENERS AND COMPOSITIONS COMPRISING THE SAME MILLIKEN & COMPANY 2013-10-24 US disclosed
US-8454711-B2 Optical brighteners and compositions comprising the same MILLIKEN & COMPANY (US) 2013-06-04 US disclosed
US-20120329699-A1 OPTICAL BRIGHTENERS AND COMPOSITIONS COMPRISING THE SAME MILLIKEN & COMPANY (US) 2012-12-27 US disclosed
US-8262744-B2 Optical brighteners and compositions comprising the same MILLIKEN & COMPANY (US) 2012-09-11 US disclosed
EP-2345541-B1 Thermosensitive recording material and image recording method RICOH CO LTD (JP) 2012-08-29 EP disclosed
WO-2011146604-A2 OPTICAL BRIGHTENERS AND COMPOSITIONS COMPRISING THE SAME MILLIKEN & COMPANY (US) 2011-11-24 WO disclosed
US-20110287999-A1 OPTICAL BRIGHTENERS AND COMPOSITIONS COMPRISING THE SAME MILLIKEN & COMPANY 2011-11-24 US disclosed
EP-2345541-A2 Thermosensitive recording material and image recording method Ricoh Company, Ltd. (JP) 2011-07-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140142305-A1 NOVEL BIS-(TRIAZINYLAMINO)-STILBENE DERIVATIVES TSN, SMARCB1, TXLNA ENPP2 1653/4885CA12 3610/4885CA1 4714/4885
US-20110287999-A1 OPTICAL BRIGHTENERS AND COMPOSITIONS COMPRISING THE SAME DBN1, AOC1, RARB ENPP2 754/4885CA12 3343/4885CA1 3242/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.