Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | PIM1 | P11309 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.59 |
| ▸ | CASP7 | P55210 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | PDE9A | O76083 | 1/20 | 0.49 |
| ▸ | MAP2 | P11137 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8923670 | 0.84 | KDM4E (0.55) | MAPTPIM1KDM4E | |
| SCHEMBL5211637 | 0.82 | ALDH1A1 (0.68) | MAPTKDM4EALDH1A1GAACASP1 | |
| SCHEMBL6702846 | 0.78 | KDM4E (0.68) | MAPTKDM4EALDH1A1GAAHPGD | |
| SCHEMBL14485203 | 0.77 | KDM4E (0.65) | MAPTPIM1KDM4EALDH1A1GAA | |
| SCHEMBL31146266 | 0.77 | KDM4E (0.65) | MAPTPIM1KDM4EALDH1A1GAA | |
| SCHEMBL28132803 | 0.77 | MAPT (0.71) | MAPTKDM4EALDH1A1GAAEGFR | |
| SCHEMBL4660958 | 0.77 | KDM4E (0.60) | MAPTPIM1KDM4EALDH1A1GAA | |
| SCHEMBL3743399 | 0.76 | KDM4E (0.70) | MAPTKDM4EALDH1A1GAAHPGD | |
| SCHEMBL4468686 | 0.76 | KDM4E (0.68) | MAPTKDM4EALDH1A1GAACASP1 | |
| SCHEMBL4455323 | 0.76 | MAPT (1.00) | MAPTKDM4EALDH1A1PDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004193-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | Merck & Co., Inc. (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007108968-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2007-09-27 | — | — | WO | disclosed |