Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | CASP1 | P29466 | 1/20 | 0.60 |
| ▸ | CASP7 | P55210 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 2/20 | 0.55 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | DDO | Q99489 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | PRKACG | P22612 | 1/20 | 0.44 |
| ▸ | PRKACB | P22694 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11372144 | 0.81 | KDM4E (0.65) | KDM4EALDH1A1GAAMAPTCASP1 | |
| SCHEMBL31146266 | 0.78 | KDM4E (0.65) | KDM4EALDH1A1GAAMAPTCASP1 | |
| SCHEMBL14485203 | 0.78 | KDM4E (0.65) | KDM4EALDH1A1GAAMAPTCASP1 | |
| SCHEMBL9457713 | 0.78 | KDM4E (0.53) | KDM4EALDH1A1GAAMAPTCASP1 | |
| SCHEMBL4660869 | 0.77 | MAPT (0.60) | KDM4EALDH1A1GAAMAPTCASP1 | |
| SCHEMBL3743077 | 0.76 | KDM4E (0.67) | KDM4EALDH1A1GAAMAPTCASP1 | |
| SCHEMBL6702846 | 0.76 | KDM4E (0.68) | KDM4EALDH1A1GAAMAPTHPGD | |
| SCHEMBL379103 | 0.75 | KDM4E (1.00) | KDM4EALDH1A1GAAMAPTCASP1 | |
| SCHEMBL29612371 | 0.75 | KDM4E (1.00) | KDM4EALDH1A1GAAMAPTCASP1 | |
| SCHEMBL28516422 | 0.75 | KDM4E (0.66) | KDM4EALDH1A1GAAMAPTCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004193-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | Merck & Co., Inc. (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007108968-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2007-09-27 | — | — | WO | disclosed |