Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 3/20 | 0.34 |
| ▸ | SNCA | P37840 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1283214 | 0.81 | TTR (0.41) | TTRTAAR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL16039290 | 0.73 | ALDH1A1 (0.50) | TTRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL29291497 | 0.69 | SNCA (0.53) | TTRSNCAMEN1KMT2AALDH1A1 | |
| SCHEMBL10180093 | 0.68 | ATM (0.40) | TTRSNCAGRIN2DGRIN3BGRIN1 | |
| SCHEMBL18959391 | 0.66 | TAAR1 (0.38) | TTRTAAR1 | |
| SCHEMBL11793625 | 0.66 | GPR35 (0.48) | TTRSNCAMEN1KMT2ALMNA | |
| SCHEMBL12458282 | 0.66 | ATM (0.41) | TTRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL1905941 | 0.65 | MEN1 (0.50) | MEN1KMT2ALMNAHTTALDH1A1 | |
| SCHEMBL9820291 | 0.65 | GAA (0.45) | MEN1KMT2ALMNAHTTALDH1A1 | |
| SCHEMBL25353394 | 0.64 | GRIN2D (0.42) | TTRGRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004193-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | Merck & Co., Inc. (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007108968-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2007-09-27 | — | — | WO | disclosed |