Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Piperidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CHKA | P35790 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperidine SCHEMBL28006849 | 0.92 | ALDH1A1 (0.47) | ALDH1A1FFAR3CA2CHKATSHR | |
| Piperidine SCHEMBL28047155 | 0.90 | FFAR3 (0.50) | ALDH1A1FFAR3LCKFYNCA2 | |
| Piperidine SCHEMBL192668 | 0.89 | ALDH1A1 (0.56) | ALDH1A1FFAR3LCKFYNCA2 | |
| Piperidine SCHEMBL10332243 | 0.89 | ALDH1A1 (0.56) | ALDH1A1FFAR3LCKFYNCA2 | |
| Piperidine SCHEMBL29043025 | 0.89 | ALDH1A1 (0.56) | ALDH1A1FFAR3LCKFYNCA2 | |
| Piperidine SCHEMBL1049754 | 0.87 | ALDH1A1 (0.53) | ALDH1A1FFAR3LCKFYNCA2 | |
| Piperidine SCHEMBL23420322 | 0.87 | ALDH1A1 (0.38) | ALDH1A1FFAR3 | |
| Piperidine SCHEMBL66142 | 0.87 | — | — | |
| Pyrrolidine SCHEMBL2797002 | 0.87 | — | — | |
| Piperidine SCHEMBL15571721 | 0.84 | ALDH1A1 (0.50) | ALDH1A1FFAR3LCKFYNCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699753-A4 | IMPROVED PROCESS FOR THE PREPARATION OF ENTACAPONE | SUVEN LIFE SCIENCES LTD (IN) | 2008-12-31 | — | — | EP | disclosed |
| EP-1699753-A1 | IMPROVED PROCESS FOR THE PREPARATION OF ENTACAPONE | Suven Life Sciences Limited (IN) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005063693-A1 | IMPROVED PROCESS FOR THE PREPARATION OF ENTACAPONE | SUVEN LIFE SCIENCES LTD (IN) | 2005-07-14 | — | — | WO | disclosed |