Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.40 |
| ▸ | JAK1 | P23458 | 8/20 | 0.40 |
| ▸ | TYK2 | P29597 | 8/20 | 0.40 |
| ▸ | JAK3 | P52333 | 8/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | MELK | Q14680 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4661452 | 0.83 | CXCL8 (0.36) | CDK4CCNE1CDK2AURKAP2RX7 | |
| SCHEMBL4661248 | 0.82 | POLB (0.47) | SYKMAPT | |
| SCHEMBL4662702 | 0.81 | JAK2 (0.42) | JAK2JAK1TYK2JAK3CNR2 | |
| SCHEMBL4662731 | 0.76 | PTPN1 (0.34) | RAB9AALDH1A1 | |
| SCHEMBL4347258 | 0.73 | MEN1 (0.49) | JAK2JAK1TYK2JAK3CNR2 | |
| SCHEMBL4661441 | 0.72 | CDK4 (0.36) | CDK4CDK2MAPK14P2RX7MAPT | |
| SCHEMBL4661367 | 0.71 | ACACB (0.42) | — | |
| SCHEMBL4661324 | 0.70 | PTPN1 (0.39) | MAPTALDH1A1L3MBTL1 | |
| SCHEMBL28339089 | 0.70 | TDP1 (0.45) | RAB9AALDH1A1 | |
| SCHEMBL22280477 | 0.70 | CNR2 (0.49) | JAK2JAK1TYK2JAK3CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007707-A1 | COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR | Boehringer Ingelheim International GmbH (DE) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007118041-A1 | COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-10-18 | — | — | WO | disclosed |