Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.42 |
| ▸ | JAK1 | P23458 | 8/20 | 0.42 |
| ▸ | TYK2 | P29597 | 8/20 | 0.42 |
| ▸ | JAK3 | P52333 | 8/20 | 0.42 |
| ▸ | CDK4 | P11802 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | MELK | Q14680 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4661449 | 0.83 | CDK4 (0.38) | CDK4CDK2CCNE1AOC3ADRB2 | |
| SCHEMBL4661583 | 0.83 | CDK4 (0.38) | CDK4CDK2CCNE1AOC3ADRB2 | |
| SCHEMBL4661242 | 0.82 | POLB (0.45) | CDK4CDK2SYKMAPT | |
| SCHEMBL4662703 | 0.81 | JAK2 (0.40) | JAK2JAK1TYK2JAK3CDK4 | |
| SCHEMBL4347258 | 0.77 | MEN1 (0.49) | JAK2JAK1TYK2JAK3CDK4 | |
| SCHEMBL4662728 | 0.76 | MMP2 (0.43) | AOC3RAB9A | |
| SCHEMBL4661434 | 0.72 | CDK4 (0.40) | CDK4CDK2MAPT | |
| SCHEMBL4661365 | 0.71 | ACACB (0.43) | — | |
| SCHEMBL4662765 | 0.71 | CDK4 (0.38) | CDK4CDK2 | |
| SCHEMBL4661323 | 0.70 | ALDH1A1 (0.41) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007707-A1 | COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR | Boehringer Ingelheim International GmbH (DE) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007118041-A1 | COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-10-18 | — | — | WO | disclosed |