Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.76 |
| ▸ | HTT | P42858 | 4/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | NAMPT | P43490 | 3/20 | 0.64 |
| ▸ | CA12 | O43570 | 2/20 | 0.63 |
| ▸ | CA9 | Q16790 | 2/20 | 0.63 |
| ▸ | CA1 | P00915 | 1/20 | 0.63 |
| ▸ | CA2 | P00918 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27083363 | 0.90 | SMN1; SMN2 (0.82) | SMN1; SMN2LMNAKEAP1HTTTDP1 | |
| SCHEMBL407414 | 0.87 | KEAP1 (1.00) | SMN1; SMN2LMNAKEAP1HTTCA12 | |
| Hydrochloric Acid SCHEMBL3516799 | 0.85 | KEAP1 (0.96) | SMN1; SMN2LMNAKEAP1HTTCA12 | |
| SCHEMBL27083360 | 0.84 | SMN1; SMN2 (0.73) | SMN1; SMN2LMNAHTTNAMPTRAB9A | |
| SCHEMBL7663045 | 0.83 | SMN1; SMN2 (0.71) | SMN1; SMN2LMNAHTTNAMPTCA12 | |
| SCHEMBL18725052 | 0.83 | KEAP1 (0.71) | SMN1; SMN2LMNAKEAP1NAMPTCA12 | |
| SCHEMBL3923271 | 0.83 | SMN1; SMN2 (0.71) | SMN1; SMN2LMNAHTTNAMPTRAB9A | |
| SCHEMBL11177620 | 0.83 | TDP1 (1.00) | SMN1; SMN2LMNAHTTTDP1CA1 | |
| SCHEMBL4895465 | 0.83 | SMN1; SMN2 (0.71) | SMN1; SMN2LMNAHTTNAMPTRAB9A | |
| SCHEMBL19358884 | 0.83 | CXCR4 (0.73) | SMN1; SMN2LMNAKEAP1HTTNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1355807-A | Thiazoloindolinone compounds | GLAXO GROUP LTD (GB) | 2002-06-26 | — | — | CN | claimed |
| WO-2022217239-A1 | INHIBITORS OF PU.1 FOR THE TREATMENT OF DISEASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2022-10-13 | — | — | WO | disclosed |
| CN-107820429-B | Novel compositions and methods for immunotherapy comprising small molecule integrin receptor-ligand agonist adjuvants | 7山药物有限责任公司 | 2022-08-16 | — | — | CN | disclosed |
| CN-107820429-A | Include the new compositions and method for immunization therapy of small molecule integrin receptors ligand activator adjuvant | 7山利益有限责任公司 | 2018-03-20 | — | — | CN | disclosed |
| WO-2015195684-A2 | SMALL MOLECULE ANTI-SCARRING AGENTS | UNIVERSITY OF ROCHESTER (US) | 2015-12-23 | — | — | WO | disclosed |
| EP-2007760-A1 | NOVEL SUBSTITUTED-1, 1-DIOXO-BENZO[1,2,4]THIADIZIN-3-ONES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007108569-A1 | NOVEL SUBSTITUTED-1, 1-DIOXO-BENZO[1,2,4]THIADIZIN-3-ONES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | KOREA RESERACH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2007-09-27 | — | — | WO | disclosed |
| EP-1633732-A1 | BENZYL SULFONAMIDE DERIVATIVES AS ANDROGEN RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 2006-03-15 | — | — | EP | disclosed |
| EP-1492793-A1 | NEW-4-(PYRROLOPYRIMIDIN-6-YL)BENZENESULPHONAMIDE DERIVATIVES | Almirall Prodesfarma, S.A. (ES) | 2005-01-05 | — | — | EP | disclosed |
| WO-2004101544-A1 | BENZYL SULFONAMIDE DERIVATIVES AS ANDROGEN RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY LLC (US) | 2004-11-25 | — | — | WO | disclosed |
| EP-1443041-A1 | 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME, MEDICINAL USE THEREOF AND INTERMEDIATES IN THE PRODUCTION THEREOF | Kissei Pharmaceutical Co., Ltd. (JP) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003082873-A1 | NEW-4-(PYRROLOPYRIMIDIN-6-YL)BENZENESULPHONAMIDE DERIVATIVES | ALMIRALL PRODESFARMA, S.A. (ES) | 2003-10-09 | — | — | WO | disclosed |
| CN-1355807-A | Thiazoloindolinone compounds | GLAXO GROUP LTD (GB) | 2002-06-26 | — | — | CN | disclosed |