Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.71 |
| ▸ | LMNA | P02545 | 7/20 | 0.71 |
| ▸ | HTT | P42858 | 6/20 | 0.71 |
| ▸ | CA12 | O43570 | 1/20 | 0.69 |
| ▸ | CA1 | P00915 | 1/20 | 0.69 |
| ▸ | CA2 | P00918 | 1/20 | 0.69 |
| ▸ | CA4 | P22748 | 1/20 | 0.69 |
| ▸ | CA6 | P23280 | 1/20 | 0.69 |
| ▸ | CA5A | P35218 | 1/20 | 0.69 |
| ▸ | CA7 | P43166 | 1/20 | 0.69 |
| ▸ | CA9 | Q16790 | 1/20 | 0.69 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.69 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | NAMPT | P43490 | 2/20 | 0.59 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27083360 | 0.85 | SMN1; SMN2 (0.73) | SMN1; SMN2LMNAHTTRAB9AALDH1A1 | |
| SCHEMBL3923271 | 0.83 | SMN1; SMN2 (0.71) | SMN1; SMN2LMNAHTTRAB9AALDH1A1 | |
| SCHEMBL4895465 | 0.83 | SMN1; SMN2 (0.71) | SMN1; SMN2LMNAHTTRAB9AALDH1A1 | |
| SCHEMBL151655 | 0.83 | KEAP1 (0.76) | SMN1; SMN2LMNACA12CA1CA2 | |
| SCHEMBL4662893 | 0.83 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAHTTCA12CA1 | |
| SCHEMBL5032594 | 0.81 | CYP19A1 (0.73) | SMN1; SMN2LMNAHTTRAB9AALDH1A1 | |
| SCHEMBL10638309 | 0.81 | CYP2C19 (0.67) | SMN1; SMN2LMNAHTTCA12CA1 | |
| SCHEMBL3789773 | 0.81 | CA2 (1.00) | HTTCA12CA1CA2CA4 | |
| SCHEMBL3571824 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2LMNAHTTRAB9AALDH1A1 | |
| SCHEMBL27083363 | 0.81 | SMN1; SMN2 (0.82) | SMN1; SMN2LMNAHTTCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492398-B1 | CYCLIN DEPENDENT KINASE 11 INHIBITORS; PREVENTING OR REDUCING SEVERITY OF EPITHELIAL CYTOTOXICITY SIDE-EFFECTS, E.G. ALOPECIA, PLANTAR-PALMAR SYNDROME, MUCOSITIS INDUCED BY CHEMOPTHERAPY AND/OR RADIATION THERAPY | SMITHKLINE BEECHMAN CORPORATION | 2002-12-10 | — | — | US | disclosed |
| EP-1159280-A2 | THIAZOLOINDOLINONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000052013-A2 | THIAZOLOINDOLINONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2000-09-08 | — | — | WO | disclosed |