Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.39 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HMGCR | P04035 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28059433 | 0.83 | NNMT (0.51) | NNMTKDM4EGLAALDH1A1GAA | |
| SCHEMBL28628579 | 0.75 | SMN1; SMN2 (0.62) | NNMTKDM4EHTTPOLBSMN1; SMN2 | |
| SCHEMBL15648561 | 0.74 | KDM4E (0.44) | NNMTKDM4EGLAALDH1A1GAA | |
| SCHEMBL3345488 | 0.72 | NNMT (0.53) | NNMTKDM4EGLAALDH1A1GAA | |
| SCHEMBL28576535 | 0.72 | HTT (0.68) | KDM4EGLAALDH1A1GAAHPGD | |
| SCHEMBL28285146 | 0.71 | CYP3A4 (0.61) | KDM4EGLAALDH1A1GAAHPGD | |
| SCHEMBL10222121 | 0.71 | NNMT (0.51) | NNMTKDM4EGLAALDH1A1GAA | |
| SCHEMBL20704256 | 0.71 | NPSR1 (0.47) | ALDH1A1HPGDHTTMAPTPOLB | |
| SCHEMBL2674736 | 0.70 | KDM4E (0.49) | NNMTKDM4EGLAALDH1A1GAA | |
| SCHEMBL118146 | 0.70 | CYP3A4 (0.44) | KDM4EGLAALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924560-A1 | 6-SUBSTITUTED- 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007028082-A1 | 6-SUBSTITUTED- 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2007-03-08 | — | — | WO | disclosed |