Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | CCR5 | P51681 | 1/20 | 0.50 |
| ▸ | PTGES | O14684 | 3/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.44 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8356647 | 1.00 | TDP1 (0.62) | TDP1CCR5PTGESALOX5ESR1 | |
| SCHEMBL5190090 | 0.93 | TDP1 (0.71) | TDP1CCR5PTGESALOX5ESR1 | |
| SCHEMBL12571026 | 0.91 | ALOX5 (0.60) | TDP1PTGESALOX5ESR1MAPT | |
| SCHEMBL12571023 | 0.89 | ALOX5 (0.57) | TDP1CCR5PTGESALOX5ESR1 | |
| SCHEMBL9289307 | 0.85 | TDP1 (0.59) | TDP1CCR5PTGESESR1MAPT | |
| SCHEMBL8008989 | 0.85 | MCHR1 (0.60) | MAPTVCAM1SERPINE1MCHR1 | |
| SCHEMBL14002193 | 0.85 | MCHR1 (0.60) | MAPTVCAM1SERPINE1MCHR1 | |
| SCHEMBL18763131 | 0.84 | TDP1 (0.64) | TDP1PTGESALOX5ESR1NR1I2 | |
| SCHEMBL8349234 | 0.84 | TDP1 (0.64) | TDP1PTGESALOX5ESR1NR1I2 | |
| SCHEMBL579010 | 0.84 | TDP1 (0.64) | TDP1PTGESALOX5ESR1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159569-A1 | DUAL HDAC6/PROTEASOME INHIBITORS, AND METHODS OF USE THEREOF | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2023-05-25 | — | — | US | disclosed |
| CN-110551044-B | Preparation method of fully-substituted propylene cyanide compound | 香港科技大学深圳研究院 | 2021-12-17 | — | — | CN | disclosed |
| CN-110551044-A | preparation method of fully-substituted propylene cyanide compound | HKUST SHENZHEN RES INSTITUTE | 2019-12-10 | — | — | CN | disclosed |
| EP-2007760-A1 | NOVEL SUBSTITUTED-1, 1-DIOXO-BENZO[1,2,4]THIADIZIN-3-ONES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007108569-A1 | NOVEL SUBSTITUTED-1, 1-DIOXO-BENZO[1,2,4]THIADIZIN-3-ONES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | KOREA RESERACH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159569-A1 | DUAL HDAC6/PROTEASOME INHIBITORS, AND METHODS OF USE THEREOF | HDAC6, PSMG3, PSMB2 | TDP1 1384/4885CCR5 4784/4885PTGES 4361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.