Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30574788 | 1.00 | ALDH1A1 (0.46) | ALDH1A1TDP1PIN1MEN1KMT2A | |
| SCHEMBL11234631 | 0.85 | PDE7A (0.50) | ALDH1A1TDP1MEN1KMT2AMAPT | |
| SCHEMBL11226790 | 0.84 | NPC1 (0.47) | ALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL6614664 | 0.83 | ALDH1A1 (0.51) | ALDH1A1TDP1MEN1KMT2ACRHBP | |
| SCHEMBL15724492 | 0.81 | KMT2A (0.51) | ALDH1A1TDP1PIN1MEN1KMT2A | |
| SCHEMBL4059206 | 0.79 | MEN1 (0.52) | ALDH1A1TDP1MEN1KMT2ACRHBP | |
| SCHEMBL11239468 | 0.79 | ABCG2 (0.41) | ALDH1A1TDP1MAPTHPGDABCG2 | |
| SCHEMBL7835308 | 0.76 | GALR2 (0.46) | ALDH1A1TDP1PIN1MEN1KMT2A | |
| SCHEMBL16520983 | 0.75 | TDP1 (0.39) | ALDH1A1TDP1PIN1MAPTRAB9A | |
| SCHEMBL12100934 | 0.74 | GSK3B (0.57) | ALDH1A1TDP1PIN1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106459036-B | Process for the preparation of 3- (3- (4- (1-aminocyclobutyl) phenyl) -5-phenyl-3H-imidazo [4,5-b ] pyridin-2-yl) pyridin-2-amine | 艾科尔公司 | 2021-07-16 | — | — | CN | claimed |
| EP-3122748-B1 | PROCESS OF PREPARING 3-(3-(4-(1-AMINOCYCLOBUTYL)PHENYL)-5-PHENYL-3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)PYRIDIN-2-AMINE | ARQULE INC (US) | 2018-09-26 | — | — | EP | claimed |
| US-9834556-B2 | Process of preparing 3-(3-(4-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-B]pyridin-2-YL)pyridin-2-amine | ARQULE, INC. (US) | 2017-12-05 | — | — | US | claimed |
| CN-106459036-A | Process of preparing 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3h-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine | 艾科尔公司 | 2017-02-22 | — | — | CN | claimed |
| EP-3122748-A1 | PROCESS OF PREPARING 3-(3-(4-(1-AMINOCYCLOBUTYL)PHENYL)-5-PHENYL-3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)PYRIDIN-2-AMINE | ArQule, Inc. (US) | 2017-02-01 | — | — | EP | claimed |
| US-20160376270-A1 | PROCESS OF PREPARING 3-(3-(4-(1-AMINOCYCLOBUTYL)PHENYL)-5-PHENYL-3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)PYRIDIN-2-AMINE | ARQULE, INC. | 2016-12-29 | — | — | US | claimed |
| US-9464083-B2 | Process of preparing 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-B]pyridin-2-yl)pyridin-2-amine | ARQULE INC. (US) | 2016-10-11 | — | — | US | claimed |
| WO-2015148464-A1 | PROCESS OF PREPARING 3-(3-(4-(1-AMINOCYCLOBUTYL)PHENYL)-5-PHENYL-3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)PYRIDIN-2-AMINE | ARQULE INC. (US) | 2015-10-01 | — | — | WO | claimed |
| US-20150266876-A1 | PROCESS OF PREPARING 3-(3-(4-(1-AMINOCYCLOBUTYL)PHENYL)-5-PHENYL-3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)PYRIDIN-2-AMINE | ARQULE, INC. | 2015-09-24 | — | — | US | claimed |
| US-20080242685-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-10-02 | — | — | US | claimed |
| EP-1940296-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007114848-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-10-11 | — | — | WO | claimed |
| US-20250115600-A1 | COVALENT MODIFIERS OF AKT1 AND USES THEREOF | TERREMOTO BIOSCIENCES, INC. | 2025-04-10 | — | — | US | disclosed |
| WO-2025059469-A1 | SUBSTITUTED AMINOPYRIDINE COMPOUNDS AS AKT INHIBITORS | ATAVISTIK BIO, INC. (US) | 2025-03-20 | — | — | WO | disclosed |
| WO-2025059577-A1 | SUBSTITUTED AMINOPYRIDINE COMPOUNDS FOR USE AS AKT1 INHIBITORS | ATAVISTIK BIO, INC. (US) | 2025-03-20 | — | — | WO | disclosed |
| WO-2025059562-A1 | SUBSTITUTED AMINOPYRIDINE COMPOUNDS AND METHODS OF TREATING DISEASE USING SAME | ATAVISTIK BIO, INC. (US) | 2025-03-20 | — | — | WO | disclosed |
| US-20080242685-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-10-02 | — | — | US | disclosed |
| EP-1940296-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007114848-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-10-11 | — | — | WO | disclosed |
| WO-2007114848-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242685-A1 | Chemical Compounds | NFKBIA, IKBKG, NFKB2 | ALDH1A1 1519/4885TDP1 1044/4885PIN1 786/4885 |
| US-20250115600-A1 | COVALENT MODIFIERS OF AKT1 AND USES THEREOF | AKT1, AKT1S1, AKT2 | ALDH1A1 4472/4885TDP1 2312/4885PIN1 1408/4885 |
| US-20150266876-A1 | PROCESS OF PREPARING 3-(3-(4-(1-AMINOCYCLOBUTYL)PHENYL)-5-PHENYL-3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)PYRIDIN-2-AMINE | PIR, PAH, PNMT | ALDH1A1 1632/4885TDP1 1826/4885PIN1 533/4885 |
| US-20160376270-A1 | PROCESS OF PREPARING 3-(3-(4-(1-AMINOCYCLOBUTYL)PHENYL)-5-PHENYL-3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)PYRIDIN-2-AMINE | PIR, PAH, PNMT | ALDH1A1 1632/4885TDP1 1826/4885PIN1 533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.