Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | ACACA | Q13085 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 2/20 | 0.41 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.40 |
| ▸ | IKBKB | O14920 | 2/20 | 0.40 |
| ▸ | CHUK | O15111 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4665017 | 0.84 | IKBKB (0.54) | PIK3CAMTORIKBKBCHUKHTR1F | |
| SCHEMBL4666771 | 0.82 | JAK2 (0.52) | HTR2BACACBACACANOS3NOS1 | |
| SCHEMBL4663350 | 0.82 | ACACB (0.51) | HTR2BACACBACACANOS3NOS1 | |
| SCHEMBL14048423 | 0.70 | SMN1; SMN2 (0.43) | HTR2BMEN1KMT2ASMN1; SMN2ACACB | |
| SCHEMBL16801703 | 0.69 | KDM4E (0.72) | HTR2BMEN1KMT2ANOS3NOS1 | |
| SCHEMBL5009877 | 0.68 | HPGDS (0.49) | MEN1KMT2A | |
| SCHEMBL1720512 | 0.68 | MEN1 (0.53) | HTR2BMEN1KMT2AACACBACACA | |
| SCHEMBL5011762 | 0.67 | IKBKB (0.48) | MEN1KMT2AL3MBTL1IKBKBCHUK | |
| SCHEMBL4664932 | 0.66 | IKBKB (0.70) | IKBKBCHUK | |
| SCHEMBL27484616 | 0.66 | MEN1 (0.68) | MEN1KMT2ALMNAL3MBTL3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242685-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-10-02 | — | — | US | claimed |
| EP-1940296-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007114848-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-10-11 | — | — | WO | claimed |
| US-20080242685-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-10-02 | — | — | US | disclosed |
| US-20080242685-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-10-02 | — | — | US | disclosed |
| EP-1940296-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007114848-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-10-11 | — | — | WO | disclosed |
| WO-2007114848-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242685-A1 | Chemical Compounds | NFKBIA, IKBKG, NFKB2 | HTR2B 2894/4885MEN1 4114/4885KMT2A 289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.