Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ACACB | O00763 | 2/20 | 0.41 |
| ▸ | ACACA | Q13085 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 6/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14048404 | 0.86 | BTK (0.37) | TSHR | |
| SCHEMBL14048399 | 0.84 | PIK3CD (0.42) | TSHRKMT2A | |
| SCHEMBL4663282 | 0.70 | HTR2B (0.44) | SMN1; SMN2ACACBACACAHTR2BACHE | |
| SCHEMBL10254838 | 0.66 | L3MBTL3 (0.61) | SMN1; SMN2ACHEPTPN2PTPN1EPHX1 | |
| SCHEMBL13801428 | 0.65 | SIGMAR1 (0.72) | ACHEPTPN2PTPN1EPHX1L3MBTL3 | |
| SCHEMBL9029952 | 0.63 | SMN1; SMN2 (0.82) | SMN1; SMN2ACHEEPHX1L3MBTL3L3MBTL1 | |
| SCHEMBL409005 | 0.63 | ACHE (0.69) | SMN1; SMN2ACHEEPHX1L3MBTL3L3MBTL1 | |
| SCHEMBL8988831 | 0.63 | ACHE (0.69) | SMN1; SMN2ACHEPTPN2PTPN1EPHX1 | |
| SCHEMBL4003983 | 0.62 | ACHE (0.73) | SMN1; SMN2ACHEEPHX1L3MBTL3L3MBTL1 | |
| SCHEMBL10755803 | 0.62 | ATM (0.50) | ACACBACACAHTR2BL3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242685-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242685-A1 | Chemical Compounds | NFKBIA, IKBKG, NFKB2 | SMN1; SMN2 4427/4885ACACB 1271/4885ACACA 1715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.