Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A7 | Q9GZV3 | 2/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.37 |
| ▸ | EP300 | Q09472 | 2/20 | 0.37 |
| ▸ | MEF2D | Q14814 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | GPX4 | P36969 | 1/20 | 0.36 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4664214 | 0.81 | SLC5A7 (0.40) | SLC5A7UTS2RMEN1KMT2AHDAC4 | |
| SCHEMBL4666227 | 0.79 | DRD2 (0.47) | SLC5A7UTS2RMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4770681 | 0.78 | SMN1; SMN2 (0.46) | SLC5A7UTS2RHDAC4EP300MEF2D | |
| SCHEMBL4664223 | 0.78 | KDM4E (0.58) | SLC5A7UTS2RMEN1KMT2AHDAC4 | |
| SCHEMBL4227919 | 0.78 | PRMT6 (0.50) | SLC5A7UTS2RMEN1KMT2ACDK2 | |
| SCHEMBL4770428 | 0.77 | MCHR1 (0.48) | MEN1KMT2A | |
| SCHEMBL4666177 | 0.77 | SLC5A7 (0.46) | SLC5A7UTS2RMEN1KMT2ACDK2 | |
| SCHEMBL3288175 | 0.72 | OPRK1 (0.46) | SLC5A7MEN1KMT2AMAOAMAOB | |
| SCHEMBL4232566 | 0.72 | KDM4E (0.43) | SLC5A7MEN1KMT2ACDK2CDK9 | |
| Hydrochloric Acid SCHEMBL4228960 | 0.71 | SMN1; SMN2 (0.48) | SLC5A7MAOAMAOBCARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891065-A1 | NOVEL MCHR1 ANTAGONISTS AND THEIR USE FOR THE TREATMENT OF MCHR1 MEDIATED CONDITIONS AND DISORDERS | AstraZeneca AB (SE) | 2008-02-27 | — | — | EP | claimed |
| WO-2006130075-A1 | NOVEL MCHR1 ANTAGONISTS AND THEIR USE FOR THE TREATMENT OF MCHR1 MEDIATED CONDITIONS AND DISORDERS | ASTRAZENECA AB (SE) | 2006-12-07 | — | — | WO | claimed |