Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2595556 | 0.96 | EPHX2 (0.47) | EPHX2ALDH1A1HPGDHSD11B1KDM4E | |
| SCHEMBL4664227 | 0.91 | EPHX2 (0.38) | EPHX2ALDH1A1HPGDHSD11B1KDM4E | |
| SCHEMBL2595560 | 0.87 | EPHX2 (0.41) | EPHX2ALDH1A1HPGDHSD11B1 | |
| SCHEMBL1078194 | 0.84 | RAF1 (0.40) | EPHX2ALDH1A1HPGDHSD11B1KDM4E | |
| SCHEMBL1078190 | 0.74 | EPHX2 (0.34) | EPHX2ALDH1A1HPGDHSD11B1KDM4E | |
| SCHEMBL26635227 | 0.74 | HSD11B1 (0.34) | EPHX2HSD11B1 | |
| SCHEMBL7449809 | 0.73 | HSD11B1 (0.51) | EPHX2ALDH1A1HPGDHSD11B1KDM4E | |
| SCHEMBL30338318 | 0.72 | MEN1 (0.47) | ALDH1A1HSD11B1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL17894911 | 0.69 | VNN1 (0.39) | — | |
| SCHEMBL908982 | 0.68 | HSD11B1 (0.44) | EPHX2ALDH1A1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924572-A1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SmithKline Beecham Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007030366-A1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | disclosed |