Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | GPR183 | P32249 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7449807 | 0.90 | HSD11B1 (0.51) | HSD11B1ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL12431600 | 0.74 | ALDH1A1 (0.71) | HSD11B1ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL4664222 | 0.73 | EPHX2 (0.44) | HSD11B1ALDH1A1HPGDEPHX2KDM4E | |
| SCHEMBL1078194 | 0.73 | RAF1 (0.40) | HSD11B1ALDH1A1HPGDEPHX2KDM4E | |
| SCHEMBL5805385 | 0.73 | ALDH1A1 (0.70) | HSD11B1ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL2595556 | 0.72 | EPHX2 (0.47) | HSD11B1ALDH1A1HPGDEPHX2KDM4E | |
| SCHEMBL1464875 | 0.70 | AKR1C3 (0.41) | ALDH1A1HPGDKDM4ESMN1; SMN2EPHX1 | |
| SCHEMBL5094333 | 0.70 | HSD11B1 (0.67) | HSD11B1ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL17804163 | 0.69 | HSD11B1 (0.66) | HSD11B1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL348724 | 0.68 | HSD11B1 (1.00) | HSD11B1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095025-A2 | BENZIMIDAZOLES, PRODUCTION THEREOF AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM KG (DE) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000001704-A2 | BENZIMIDAZOLES, PRODUCTION THEREOF AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-01-13 | — | — | WO | disclosed |