Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CASP2 | P42575 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17335855 | 0.65 | HPGD (0.73) | HPGDHSD17B10POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL2633147 | 0.65 | CASP2 (0.70) | HPGDALDH1A1CASP2 | |
| SCHEMBL1690856 | 0.63 | HPGD (0.71) | HPGDALDH1A1 | |
| SCHEMBL2794119 | 0.63 | LMNA (0.56) | HPGDHSD17B10KDM4EPOLBMAPT | |
| SCHEMBL840681 | 0.63 | — | — | |
| SCHEMBL16120761 | 0.62 | PTGS1 (0.46) | HPGDMAPTTSHRALDH1A1MTNR1A | |
| SCHEMBL2724897 | 0.62 | HPGD (0.73) | HPGDHSD17B10KDM4EMAPTALDH1A1 | |
| SCHEMBL29126682 | 0.62 | HPGD (0.68) | HPGDHSD17B10MAPTALDH1A1 | |
| SCHEMBL14576993 | 0.61 | CASP2 (0.78) | TSHRCASP2 | |
| SCHEMBL7537764 | 0.61 | CASP2 (0.86) | HPGDCASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613606-A4 | METHODS FOR PREPARING 2,3,5,6-SUBSTITUTED 3H-PYRIMIDIN-4-ONES | NPS PHARMA INC (US) | 2008-12-03 | — | — | EP | disclosed |
| EP-1613606-A2 | METHODS FOR PREPARING 2,3,5,6-SUBSTITUTED 3H-PYRIMIDIN-4-ONES | NPS PHARMACEUTICALS, INC. (US) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004092121-A2 | METHODS FOR PREPARING 2,3,5,6-SUBSTITUTED 3H-PYRIMIDIN-4-ONES | NPS PHARMACEUTICALS, INC. (US) | 2004-10-28 | — | — | WO | disclosed |