Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 14/20 | 0.62 |
| ▸ | CHUK | O15111 | 8/20 | 0.62 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.43 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4666037 | 0.84 | IKBKB (0.61) | IKBKBCHUKBRD4DHODHPARP1 | |
| SCHEMBL3802579 | 0.77 | IKBKB (1.00) | IKBKBCHUK | |
| SCHEMBL4689422 | 0.76 | IKBKB (0.97) | IKBKBCHUKDHODH | |
| SCHEMBL27698209 | 0.75 | IKBKB (0.61) | IKBKBCHUKPARP1IKBKEPKMYT1 | |
| SCHEMBL30494484 | 0.74 | HPGD (0.46) | IKBKBCHUKBRD4DHODHPARP1 | |
| SCHEMBL28064535 | 0.74 | HPGD (0.46) | IKBKBCHUKBRD4DHODHPARP1 | |
| SCHEMBL4689165 | 0.74 | IKBKB (0.91) | IKBKBCHUKDHODH | |
| SCHEMBL5044495 | 0.72 | IDO1 (0.43) | IKBKBCHUKDHODHPARP1 | |
| SCHEMBL3691963 | 0.71 | RHEB (0.60) | DHODH | |
| SCHEMBL6029606 | 0.69 | DHODH (0.78) | IKBKBCHUKBRD4DHODHPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293802-A1 | Chemical Compounds | SMITHLINE BEECHAM CORPORATION | 2008-11-27 | — | — | US | claimed |
| EP-1959737-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-08-27 | — | — | EP | claimed |
| WO-2007076286-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | claimed |
| US-20080293802-A1 | Chemical Compounds | SMITHLINE BEECHAM CORPORATION | 2008-11-27 | — | — | US | disclosed |
| US-20080293802-A1 | Chemical Compounds | SMITHLINE BEECHAM CORPORATION | 2008-11-27 | — | — | US | disclosed |
| US-20080293802-A1 | Chemical Compounds | SMITHLINE BEECHAM CORPORATION | 2008-11-27 | — | — | US | disclosed |
| EP-1959737-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007076286-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076286-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293802-A1 | Chemical Compounds | IKBKG, NFKBIA, IDO2 | IKBKB 6/4885CHUK 9/4885BRD4 185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.