Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 13/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14600206 | 0.88 | ADORA1 (0.42) | ADORA1DHODHKDM5AKDM4CKDM5B | |
| SCHEMBL14600232 | 0.85 | DHODH (0.46) | ADORA1LMNADHODHMEN1KMT2A | |
| SCHEMBL14600465 | 0.84 | DHODH (0.46) | ADORA1DHODHMAPT | |
| SCHEMBL14600450 | 0.81 | DHODH (0.43) | ADORA1DHODHMAPT | |
| SCHEMBL14600229 | 0.80 | ADORA1 (0.45) | ADORA1LMNAGAADHODH | |
| SCHEMBL14600441 | 0.78 | ADORA1 (0.56) | ADORA1DHODH | |
| SCHEMBL14600727 | 0.78 | DHODH (0.55) | ADORA1DHODHMEN1KMT2AHTT | |
| SCHEMBL14600498 | 0.78 | DHODH (0.42) | ADORA1DHODHMAPT | |
| SCHEMBL14600231 | 0.78 | SORT1 (0.50) | LMNAGAAMEN1KMT2ANPC1 | |
| SCHEMBL14600468 | 0.78 | DHODH (0.40) | ADORA1LMNAGAADHODHMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928455-A1 | ANILINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES | Bayer Healthcare, LLC (US) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007027842-A1 | ANILINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES | BAYER HEALTHCARE LLC (US) | 2007-03-08 | — | — | WO | disclosed |
| WO-2007027842-A1 | ANILINOPYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF DIABETES | BAYER HEALTHCARE LLC (US) | 2007-03-08 | — | — | WO | disclosed |